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A functional promoter polymorphism in interleukin 12B gene is associated with an increased risk of ovarian endometriosis

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机构： [1]Department of Gynecology, Fourth Hospital, Hebei Medical University, Shijiazhuang, China [2]Department of Molecular Biology, Hebei Medical University, Shijiazhuang, China

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关键词： IL12B gene mRNA expression Ovarian endometriosis Polymorphism Risk

摘要：

Objective: To explore the role of functional genetic variant of IL12B in the pathogenesis of ovarian endometriosis. Study design: This study included 815 patients with ovarian endometriosis and 788 women in the control group. Two polymorphisms were genotyped by a method of polymerase chain reaction and ligase detection reaction. To assess the biological significance of polymorphisms, we detected the level of IL12p40 protein expression in patients' eutopic endometrial tissues using quantitative real-time polymerase chain reaction (qRT-PCR). Result(s): Compared with the CTCTAA/CTCTAA genotype, the GC/GC and GC/CTCTAA genotypes of rs17860508 could significantly increase the risk of ovarian endometriosis development (OR = 1.58, 95% CI = 1.19-2.09; OR = 1.37, 95% CI = 1.08-1.74, respectively). Moreover, the IL12B mRNA was expressed at significantly higher levels in the eutopic endometrial tissue of patients with the GC/GC genotype than in patients with the CTCTAA/CTCTAA genotype. However, the rs3212227 polymorphism may not be associated with a risk of ovarian endometriosis. Conclusion(s): The rs17860508 polymorphism in the IL12B promoter region may influence the risk of developing ovarian endometriosis by altering the endometrial expression of IL12B of in Northern Chinese women.

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出版当年[2018]版：

大类 | 3 区生物

小类 | 4 区遗传学

最新[2025]版：

大类 | 3 区生物学

小类 | 3 区遗传学

JCR分区：

出版当年[2018]版：

Q2 GENETICS & HEREDITY

最新[2023]版：

Q2 GENETICS & HEREDITY

影响因子： 2.6 最新[2023版] 2.7 最新五年平均 2.638 出版当年[2018版] 2.351 出版当年五年平均 2.498 出版前一年[2017版] 2.984 出版后一年[2019版]

第一作者：

第一作者机构： [1]Department of Gynecology, Fourth Hospital, Hebei Medical University, Shijiazhuang, China

通讯作者：

通讯机构： [1]Department of Gynecology, Fourth Hospital, Hebei Medical University, Shijiazhuang, China [*1]Jiankang Street 12, Shijiazhuang 050011, China.

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