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Differentially expressed lncRNAs and mRNAs identified by NGS analysis in colorectal cancer patients

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收录情况： ◇ SCIE

作者：
Li, Meng[1,2] * ; Zhao, Lian-mei[3] ; Li, Suo-lin[1] ; Li, Jing[2] ; Gao, Bo[2] ; Wang, Fei-fei[2] ; Wang, Sheng-pu[2] ; Hu, Xu-hua[2] ; Cao, Jian[2] ; Wang, Gui-ying[2,*1] ;
机构： [1]Pediatric Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China [2]The Second General Surgery, Hebei Medical University Fourth Affiliated Hospital and Hebei Provincial Tumor Hospital, Shijiazhuang, Hebei, China [3]Research Center, Hebei Medical University Fourth Affiliated Hospital and Hebei Provincial Tumor Hospital, Shijiazhuang, Hebei, China
出处：
DOI： 10.1002/cam4.1696
ISSN：

关键词： colorectal cancer enrichment analysis lncRNAs mRNA next-generation sequencing

摘要：
Long noncoding RNAs (lncRNAs) play an important role in gene regulation, but their impact on the pathogenesis of colorectal cancer and the biological function of cancer cells is unclear. In this study, we used next-generation sequencing to study the differences in the expression profiles of lncRNAs and mRNAs in colorectal cancer tissues. We analyzed the differentially expressed genes by Gene Ontology/Kyoto Encyclopedia of Genes and Genomes (GO/KEGG) enrichment and predicted new lncRNA functions. Our results revealed that compared with lncRNAs and mRNAs in nontumor colorectal tissues, 1019 lncRNAs (512 upregulated, 507 downregulated) and 3221 mRNAs (1606 upregulated, 1615 downregulated) were differentially expressed in tumor colorectal tissues (fold change >2 and P < 0.05). We validated some of these genes by qPCR. Furthermore, we identified some new lncRNAs differently expressed in colorectal cancer samples from patients in northern China. We confirmed the function of lncRNA-FIRRE-201 and SLCO4A1-AS1-202 in colorectal cancer cells to provide an experimental basis for studies on their roles in the occurrence and development of colorectal cancer and in the regulation of networks.

基金：
National Natural Science Foundation of China, Grant/Award Number: 81502032; Natural Science Foundation of Hebei Province, Grant/Award Number: H2015206376; Health and Family Planning Commission of Hebei Province, Grant/ Award Number: 20150362; 2016 Hebei government-supported clinical medical talents; 2016 Hebei medical application technology tracking project, Grant/Award Number: GL201621
语种：
外文
被引次数：
WOS：
PubmedID：
中科院分区：
出版当年[2018]版：
大类 | 3 区 医学
小类 | 3 区 肿瘤学
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 肿瘤学
JCR分区：
出版当年[2018]版：
Q2 ONCOLOGY
最新[2023]版：
Q2 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [1]Pediatric Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China [2]The Second General Surgery, Hebei Medical University Fourth Affiliated Hospital and Hebei Provincial Tumor Hospital, Shijiazhuang, Hebei, China
通讯作者：
通讯机构： [2]The Second General Surgery, Hebei Medical University Fourth Affiliated Hospital and Hebei Provincial Tumor Hospital, Shijiazhuang, Hebei, China [*1]The Second General Surgery, Hebei Medical University Fourth Affiliated Hospital and Hebei Provincial Tumor Hospital, Hebei 050011, China
推荐引用方式(GB/T 7714)：
Li Meng,Zhao Lian-mei,Li Suo-lin,et al.Differentially expressed lncRNAs and mRNAs identified by NGS analysis in colorectal cancer patients[J].CANCER MEDICINE.2018,7(9):4650-4664.doi:10.1002/cam4.1696.
APA：
Li, Meng,Zhao, Lian-mei,Li, Suo-lin,Li, Jing,Gao, Bo...&Wang, Gui-ying.(2018).Differentially expressed lncRNAs and mRNAs identified by NGS analysis in colorectal cancer patients.CANCER MEDICINE,7,(9)
MLA：
Li, Meng,et al."Differentially expressed lncRNAs and mRNAs identified by NGS analysis in colorectal cancer patients".CANCER MEDICINE 7..9(2018):4650-4664

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