Recent studies have revealed abnormal expression of miRNAs in various tumors. Although microRNA-338-3p (miR-338-3p) plays an important role in many types of tumors, its influence on liver cancer (LC) is unknown. In this study, we found that expression of miR-338-3p was decreased in LC cells and tissues. Colony formation and cell proliferation were suppressed by enhanced expression of miR-338-3p in LC cells. Moreover, miR-338-3p targeted sphingosine kinase 2 (SphK2). Silencing of SphK2 had an identical influence as overexpression of miR-338-3p in LC cells. Overexpression of SphK2 without the 3'-untranslated region remarkably enhanced the growth suppression triggered by miR-338-3p in LC cells. These findings indicate that miR-338-3p influences the development of LC by targeting SphK2, suggesting that miR-338-3p can be targeted as an innovative therapeutic strategy for LC.
基金：
Key Project of Medical Science Research in Hebei Province [20150335]
第一作者机构：[1]ShaoXing Municipal Hosp, Dept Oncol, Shaoxing, Zhejiang, Peoples R China
通讯作者：
通讯机构：[1]ShaoXing Municipal Hosp, Dept Oncol, Shaoxing, Zhejiang, Peoples R China[2]Hebei Med Univ, Hosp 4, Dept Intervent Radiol, 12 Jian Kang Rd, Shijiazhuang 050011, Hebei, Peoples R China[*1]Department of Interventional Radiology, The 4th Hospital of Hebei Medical University, #12 Jian Kang Road, Shi Jiazhuang, Hebei 050011, P.R. China
推荐引用方式(GB/T 7714)：
Xiao Geqiong,Wang Qiong,Li Bo,et al.MicroRNA-338-3p Suppresses Proliferation of Human Liver Cancer Cells by Targeting SphK2[J].ONCOLOGY RESEARCH.2018,26(8):1183-1189.doi:10.3727/096504018X15151495109394.
APA：
Xiao, Geqiong,Wang, Qiong,Li, Bo,Wu, Xiaohui,Liao, Hui...&Ai, Ning.(2018).MicroRNA-338-3p Suppresses Proliferation of Human Liver Cancer Cells by Targeting SphK2.ONCOLOGY RESEARCH,26,(8)
MLA：
Xiao, Geqiong,et al."MicroRNA-338-3p Suppresses Proliferation of Human Liver Cancer Cells by Targeting SphK2".ONCOLOGY RESEARCH 26..8(2018):1183-1189
