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MAGE-A gene expression in peripheral blood serves as a poor prognostic marker for patients with lung cancer

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机构： [1]Hebei Med Univ, Res Ctr, Hosp 4, 14 Jiankang Rd, Shijiazhuang 050017, Hebei, Peoples R China [2]Hebei Med Univ, Tumor Res Inst, Hosp 4, Shijiazhuang, Hebei, Peoples R China

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关键词： Biological marker lung cancer MAGE metastasis prognosis

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BackgroundMAGE-A genes belong to the cancer/testis antigens family. The prognostic significance of MAGE-A expression in the peripheral blood of patients with lung cancer is unknown. Therefore, this study evaluated the expression and possible prognostic significance of MAGE-A in the peripheral blood of patients with lung cancer. MethodsIn this study, we detected MAGE-A gene expression in the peripheral blood of 150 patients with lung cancer and 30 healthy donors using multiplex semi-nested PCR and analyzed their correlation with clinicopathological risk factors. ResultsMAGE-A expression was associated with factors indicating poor prognosis. The expression of MAGE-A and each individual MAGE-A gene were also associated with low overall survival in patients with lung cancer. ConclusionThe expression of MAGE-A genes in peripheral blood may act as a poor prognostic marker in patients with lung cancer.

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出版当年[2018]版：

大类 | 4 区医学

小类 | 4 区肿瘤学 4 区呼吸系统

最新[2025]版：

大类 | 4 区医学

小类 | 4 区肿瘤学 4 区呼吸系统

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出版当年[2018]版：

Q3 RESPIRATORY SYSTEM Q3 ONCOLOGY

最新[2024]版：

Q2 RESPIRATORY SYSTEM Q3 ONCOLOGY

影响因子： 2.3 最新[2024版] 2.7 最新五年平均 2.524 出版当年[2018版] 1.889 出版当年五年平均 2.569 出版前一年[2017版] 2.61 出版后一年[2019版]

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第一作者机构： [1]Hebei Med Univ, Res Ctr, Hosp 4, 14 Jiankang Rd, Shijiazhuang 050017, Hebei, Peoples R China

通讯作者：

通讯机构： [1]Hebei Med Univ, Res Ctr, Hosp 4, 14 Jiankang Rd, Shijiazhuang 050017, Hebei, Peoples R China [2]Hebei Med Univ, Tumor Res Inst, Hosp 4, Shijiazhuang, Hebei, Peoples R China [*1]Research Center, The Fourth Hospital of Hebei Medical University, 14 Jiankang Road, Shijiazhuang, Hebei 050017, China.

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