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Peroxiredoxin 4 (PRDX4): Its critical in vivo roles in animal models of metabolic syndrome ranging from atherosclerosis to nonalcoholic fatty liver disease

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收录情况： ◇ SCIE

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机构： [1]Department of Pathology and Laboratory Medicine, Kanazawa Medical University, Ishikawa, Japan and [2]Laboratory of Pathology, Hebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Hebei, China

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关键词： animal model chronic inflammatory disease human PRDX4 transgenic mice (Tg) metabolic syndrome peroxiredoxin (PRDX) 4

摘要：

The peroxiredoxin (PRDX) family, a new family of proteins with a pivotal antioxidative function, is ubiquitously synthesized and abundantly identified in various organisms. In contrast to the intracellular localization of other family members (PRDX1/2/3/5/6), PRDX4 is the only known secretory form and protects against oxidative damage by scavenging reactive oxygen species in both the intracellular (especially the endoplasmic reticulum) compartments and the extracellular space. We generated unique human PRDX4 (hPRDX4) transgenic (Tg) mice on a C57BL/6J background and investigated the critical and diverse protective roles of PRDX4 against diabetes mellitus, atherosclerosis, insulin resistance, and nonalcoholic fatty liver disease (NAFLD) as well as evaluated its role in the intestinal function in various animal models. Our published data have shown that PRDX4 helps prevent the progression of metabolic syndrome by reducing local and systemic oxidative stress and synergistically suppressing steatosis, inflammatory reactions, and/or apoptotic activity. These observations suggest that Tg mice may be a useful animal model for studying the relevance of oxidative stress on inflammation and the dysregulation of lipid/bile acid/glucose metabolism upon the progression of human metabolic syndrome, and that specific accelerators of PRDX4 may be useful as therapeutic agents for ameliorating various chronic inflammatory diseases.

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出版当年[2018]版：

大类 | 4 区医学

小类 | 4 区病理学

最新[2025]版：

大类 | 4 区医学

小类 | 3 区病理学

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出版当年[2018]版：

Q2 PATHOLOGY

最新[2023]版：

Q2 PATHOLOGY

影响因子： 2.5 最新[2023版] 2.3 最新五年平均 2.082 出版当年[2018版] 1.852 出版当年五年平均 1.742 出版前一年[2017版] 2.11 出版后一年[2019版]

第一作者：

第一作者机构： [1]Department of Pathology and Laboratory Medicine, Kanazawa Medical University, Ishikawa, Japan and [*1]Department of Pathology and Laboratory Medicine, Kanazawa Medical University, 1-1 Uchinada, Ishikawa 920-0293, Japan.

通讯作者：

通讯机构： [1]Department of Pathology and Laboratory Medicine, Kanazawa Medical University, Ishikawa, Japan and [*1]Department of Pathology and Laboratory Medicine, Kanazawa Medical University, 1-1 Uchinada, Ishikawa 920-0293, Japan.

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