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Over-regulation of microRNA-133b inhibits cell proliferation of cisplatin-induced non-small cell lung cancer cells through PI3K/Akt and JAK2/STAT3 signaling pathway by targeting EGFR

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Li, Bin[1,*1] * ; Ding, Cui-Min[1] ; Li, Yan-Xiao[2] ; Peng, Jing-Cui[1] ; Geng, Nan[1] ; Qin, Wen-Wen[1] ;
机构： [1]Department of Respiratory Medicine, Fourth Hospital of Hebei Medical University [2]Department of Respiratory Medicine, First Hospital of Shijiazhuang, Hebei 050011, P.R. China
出处：
DOI： 10.3892/or.2018.6215
ISSN：

关键词： microRNA-133b non-small cell lung cancer cells Akt STAT3 EGFR

摘要：
The present study determined the anticancer activity and its mechanism of microRNA-133b on cell proliferation of cisplatin-induced non-small cell lung cancer cells. The expression of microRNA-133b cisplatin-induced non-small cell lung cancer (NSCLC) tissue was lower than that of para-carcinoma tissue in patients. Overall survival of higher expression in cisplatin-induced NSCLC patients was higher than that of lower expression in cisplatin-induced NSCLC patients. Over-regulation of microRNA-133b inhibited cell proliferation and LDH activity, induced apoptosis and caspase-3 activity, suppressed the protein expression of EGFR, PI3K, p-Akt, p-JAK2 and p-STAT3, decreased cyclin D1 and increased Bax protein expression in cisplatin-induced A549 cells. EGFR inhibitor (lapatinib) suppressed EGFR protein expression, inhibited cell proliferation and LDH activity, and induced apoptosis and caspase-3 activity in cisplatin-induced A549 cells by over-regulation of microRNA-133b. When EGFR protein expression was suppressed, PI3K, p-Akt, p-JAK2 and p-STAT3, decreased cyclin D1 and increased Bax protein expression in cisplatin-induced A549 cells by over-regulation of microRNA-133b. Altogether, our results indicated that over-regulation of microRNA-133b inhibits cell proliferation of cisplatin-induced NSCLC by PI3K/Akt and JAK2/STAT3 signaling pathway by targeting EGFR.

语种：
外文
被引次数：
WOS：
PubmedID：
中科院分区：
出版当年[2018]版：
大类 | 3 区 医学
小类 | 4 区 肿瘤学
最新[2025]版：
大类 | 3 区 医学
小类 | 4 区 肿瘤学
JCR分区：
出版当年[2018]版：
Q2 ONCOLOGY
最新[2024]版：
Q2 ONCOLOGY

影响因子： 最新[2024版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [1]Department of Respiratory Medicine, Fourth Hospital of Hebei Medical University [*1]Department of Respiratory Medicine, Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Hebei 050011, P.R. China
通讯作者：
通讯机构： [1]Department of Respiratory Medicine, Fourth Hospital of Hebei Medical University [*1]Department of Respiratory Medicine, Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Hebei 050011, P.R. China
推荐引用方式(GB/T 7714)：
Li Bin,Ding Cui-Min,Li Yan-Xiao,et al.Over-regulation of microRNA-133b inhibits cell proliferation of cisplatin-induced non-small cell lung cancer cells through PI3K/Akt and JAK2/STAT3 signaling pathway by targeting EGFR[J].ONCOLOGY REPORTS.2018,39(3):1227-1234.doi:10.3892/or.2018.6215.
APA：
Li, Bin,Ding, Cui-Min,Li, Yan-Xiao,Peng, Jing-Cui,Geng, Nan&Qin, Wen-Wen.(2018).Over-regulation of microRNA-133b inhibits cell proliferation of cisplatin-induced non-small cell lung cancer cells through PI3K/Akt and JAK2/STAT3 signaling pathway by targeting EGFR.ONCOLOGY REPORTS,39,(3)
MLA：
Li, Bin,et al."Over-regulation of microRNA-133b inhibits cell proliferation of cisplatin-induced non-small cell lung cancer cells through PI3K/Akt and JAK2/STAT3 signaling pathway by targeting EGFR".ONCOLOGY REPORTS 39..3(2018):1227-1234

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