Heterogeneity in esophageal and gastric cardia precursor progression during six-year endoscopic surveillance after population-based screening in a Chinese high-risk region
机构：[1]Cancer Center, Fourth Hospital of Hebei Medical University, Shijiazhuang, China河北医科大学第四医院[2]Medical Information, Affiliated Hospital, Niigata University, Niigata, Japan
BackgroundThe study was conducted to examine esophageal and gastric cardia precursor progression. MethodsAfter population-based baseline screening, 145 precursor and 335 chronic inflammation cases were endoscopically surveyed for sixyears. ResultsSurveillance of interval and baseline diagnoses for 18 severe dysplasia (SD) cases later detected were: 13, 23, 39, and 44months since a diagnosis of chronic inflammation in four cases; 6, 6, 6, 11, 13, 16, 16, and 23months since mild dysplasia (mD) diagnoses in eight; and 6, 9, 10, 13, 18, and 48months since moderate dysplasia (MD) diagnoses in six. Rates for 11 carcinoma in situ (Cis) cases later detected were: 7 and 18months since basal cell hyperplasia (Bch) diagnoses in two; and 6, 6, 9, 13, 13, 18, 35, 44, and 50months since MD diagnoses in nine. In 10 cancer cases later detected, rates were: 6, 6, 7, 18, 19, 34, 36, and 48months since SD diagnoses in eight cases with submucosal carcinoma; 46months since MD diagnosis in a T2N0M0 carcinoma case; and 52months since Bch diagnosis in another T2N0M0 case. ConclusionEsophageal and gastric cardia precursors are heterogeneous. Male gender, advanced age, family history of upper gastrointestinal cancer, and multifocal dysplasia are significant independent predictors for progression, and Bch/mD, MD, and SD constitute three distinctive entities regarding the risk of cancer.
基金：
Key Medical Research Subjects in Hebei Province [2056]; Grants-in-Aid for Scientific ResearchMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [16H05825] Funding Source: KAKEN
第一作者机构：[1]Cancer Center, Fourth Hospital of Hebei Medical University, Shijiazhuang, China
通讯作者：
通讯机构：[1]Cancer Center, Fourth Hospital of Hebei Medical University, Shijiazhuang, China[*1]Cancer Center, Fourth Hospital of Hebei Medical University, Jiankanglu 12, Shijiazhuang 050011, China.
推荐引用方式(GB/T 7714)：
Wen Denggui,Zhang Liwei,Wang Xiaoling,et al.Heterogeneity in esophageal and gastric cardia precursor progression during six-year endoscopic surveillance after population-based screening in a Chinese high-risk region[J].THORACIC CANCER.2017,8(4):328-336.doi:10.1111/1759-7714.12446.
APA：
Wen, Denggui,Zhang, Liwei,Wang, Xiaoling,Wen, Xiaoduo,Yang, Yi...&Shan, Baoen.(2017).Heterogeneity in esophageal and gastric cardia precursor progression during six-year endoscopic surveillance after population-based screening in a Chinese high-risk region.THORACIC CANCER,8,(4)
MLA：
Wen, Denggui,et al."Heterogeneity in esophageal and gastric cardia precursor progression during six-year endoscopic surveillance after population-based screening in a Chinese high-risk region".THORACIC CANCER 8..4(2017):328-336
