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Biomarkers for EMT and MET in breast cancer: An update

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机构: [1]Hebei Med Univ, Hosp 4, Tumor Res Inst, 12 Jiankang Rd, Shijiazhuang 050017, Hebei, Peoples R China [2]Hebei Med Univ, Hosp 4, Res Ctr, Shijiazhuang 050017, Hebei, Peoples R China [3]Hebei Med Univ, Hosp 4, Breast Ctr, Shijiazhuang 050017, Hebei, Peoples R China
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关键词: breast cancer epithelial-mesenchymal transition mesenchymal-epithelial transition biomarker microRNA protein kinase

摘要:
Metastasis and recurrence are the leading cause of mortality due to breast cancer, but the underlying mechanisms are still poorly understood. Understanding the breast cancer metastasis mechanism is important for early diagnosis and treatment of breast cancer. The seeding and growth of breast cancer cells at sites distinct from the primary tumor is a complex and multistage process. Recently, it has been reported that the epithelial-mesenchymal transition (EMT) and the mesenchymal-epithelial transition (MET) are the main mechanisms for breast cancer metastasis. During EMT, carcinoma cells shed their differentiated epithelial characteristics, including cell-cell adhesion, polarity and lack of motility, and acquire mesenchymal traits, including motility and invasiveness. This review has summarized the studies of known EMT biomarkers in the context of breast cancer progression. These biomarkers include EMT-related genes, proteins, microRNAs and kinases. In general, the findings of these studies suggest that EMT markers are associated with the invasion and metastasis of breast cancer. Further studies on the link between EMT markers and breast cancer will contribute to identify biomarkers for predicting early breast cancer metastasis as well as to provide new ideas for the treatment of breast cancer.

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出版当年[2016]版:
大类 | 4 区 医学
小类 | 4 区 肿瘤学
最新[2025]版:
大类 | 4 区 医学
小类 | 4 区 肿瘤学
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出版当年[2016]版:
Q4 ONCOLOGY
最新[2023]版:
Q3 ONCOLOGY

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第一作者机构: [1]Hebei Med Univ, Hosp 4, Tumor Res Inst, 12 Jiankang Rd, Shijiazhuang 050017, Hebei, Peoples R China [2]Hebei Med Univ, Hosp 4, Res Ctr, Shijiazhuang 050017, Hebei, Peoples R China
通讯作者:
通讯机构: [1]Hebei Med Univ, Hosp 4, Tumor Res Inst, 12 Jiankang Rd, Shijiazhuang 050017, Hebei, Peoples R China [2]Hebei Med Univ, Hosp 4, Res Ctr, Shijiazhuang 050017, Hebei, Peoples R China [*1]Tumor Research Institute, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, Hebei 050017, P.R. China
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