Like many tumor suppressor genes, some miRNA genes harboring CpG islands undergo methylation-mediated silencing. In the study, we found significant downregulation and proximal promoter methylation of miR-203a and miR-203b in gastric cardia adenocarcinoma (GCA) tissues. The methylation status of miR-203a and miR-203b in tumor tissues was negatively correlated with their expression level. GCA patients in stage III and IV with reduced expression or hypermethylation of miR-203a demonstrated poor patient survival. In all, miR-203a and miR-203b may function as tumor suppressive miRNAs, and reactivation of miR-203a may have therapeutic potential and may be used as prognostic marker for GCA patients.
第一作者机构：[1]Hebei Med Univ, Hosp 4, Hebei Canc Inst, Pathol Lab, Jiankang Rd 12, Shijiazhuang 050011, Hebei, Peoples R China[2]Cangzhou Cent Hosp, Dept Surg Oncol, Cangzhou, Hebei, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Hebei Med Univ, Hosp 4, Hebei Canc Inst, Pathol Lab, Jiankang Rd 12, Shijiazhuang 050011, Hebei, Peoples R China[*1]Laboratory of Pathology, Hebei Cancer Institute, the Fourth Hospital of HebeiMedical University, Jiankang Road 12, Shijiazhuang 050011, Hebei, China.
推荐引用方式(GB/T 7714)：
Liu Wei,Dong Zhiming,Liang Jia,et al.Downregulation of Potential Tumor Suppressor miR-203a by Promoter Methylation Contributes to the Invasiveness of Gastric Cardia Adenocarcinoma[J].CANCER INVESTIGATION.2016,34(10):506-516.doi:10.1080/07357907.2016.1242010.
APA：
Liu, Wei,Dong, Zhiming,Liang, Jia,Guo, Xin,Guo, Yanli...&Guo, Wei.(2016).Downregulation of Potential Tumor Suppressor miR-203a by Promoter Methylation Contributes to the Invasiveness of Gastric Cardia Adenocarcinoma.CANCER INVESTIGATION,34,(10)
MLA：
Liu, Wei,et al."Downregulation of Potential Tumor Suppressor miR-203a by Promoter Methylation Contributes to the Invasiveness of Gastric Cardia Adenocarcinoma".CANCER INVESTIGATION 34..10(2016):506-516
