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Downregulation of Potential Tumor Suppressor miR-203a by Promoter Methylation Contributes to the Invasiveness of Gastric Cardia Adenocarcinoma

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机构: [1]Hebei Med Univ, Hosp 4, Hebei Canc Inst, Pathol Lab, Jiankang Rd 12, Shijiazhuang 050011, Hebei, Peoples R China [2]Cangzhou Cent Hosp, Dept Surg Oncol, Cangzhou, Hebei, Peoples R China
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关键词: gastric cardia adenocarcinoma miR-203a miR-203b expression methylation

摘要:
Like many tumor suppressor genes, some miRNA genes harboring CpG islands undergo methylation-mediated silencing. In the study, we found significant downregulation and proximal promoter methylation of miR-203a and miR-203b in gastric cardia adenocarcinoma (GCA) tissues. The methylation status of miR-203a and miR-203b in tumor tissues was negatively correlated with their expression level. GCA patients in stage III and IV with reduced expression or hypermethylation of miR-203a demonstrated poor patient survival. In all, miR-203a and miR-203b may function as tumor suppressive miRNAs, and reactivation of miR-203a may have therapeutic potential and may be used as prognostic marker for GCA patients.

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出版当年[2016]版:
大类 | 3 区 医学
小类 | 4 区 肿瘤学
最新[2025]版:
大类 | 4 区 医学
小类 | 4 区 肿瘤学
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出版当年[2016]版:
Q3 ONCOLOGY
最新[2024]版:
Q3 ONCOLOGY

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第一作者机构: [1]Hebei Med Univ, Hosp 4, Hebei Canc Inst, Pathol Lab, Jiankang Rd 12, Shijiazhuang 050011, Hebei, Peoples R China [2]Cangzhou Cent Hosp, Dept Surg Oncol, Cangzhou, Hebei, Peoples R China
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通讯机构: [1]Hebei Med Univ, Hosp 4, Hebei Canc Inst, Pathol Lab, Jiankang Rd 12, Shijiazhuang 050011, Hebei, Peoples R China [*1]Laboratory of Pathology, Hebei Cancer Institute, the Fourth Hospital of HebeiMedical University, Jiankang Road 12, Shijiazhuang 050011, Hebei, China.
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