In this research, andrographolide (AG) nanosuspension was produced using wet milling method and its pharmacokinetic behavior was evaluated after intramuscular (i.m.) and oral administration. AG nano suspension was characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and differential scanning calorimetry (DSC). The crystal structure wasn't damaged by wet milling and no obvious crystal structure change was found between bulk AG and AG nanosuspension. In vitro dissolution showed a higher dissolution rate from AG nanosuspension (85.5%), compared with that of bulk AG (69.1%) at 90 min. Following intramuscularly injection, the release of AG lasted for 4 weeks. The histological examination implied that AG nanosuspension produced very few inflammation responses and gradually returned to normal after 14 d i.m. administration. These results suggested that AG nano suspension could be developed as a potential delivery system for long-acting intramuscular administration. (C) 2016 Elsevier B.V. All rights reserved.
基金：
Medical and Engineering Science Research Center of Hebei University [BM201109]; Hebei Provincial Natural Science Foundation of China-Shijiazhuang Pharmaceutical Group (CSPC) Foundation [H2013201274]; Top Young Talents Program of Hebei Province
第一作者机构：[1]Hebei Univ, Sch Pharmaceut Sci, 180 WuSi Rd, Baoding 071002, Peoples R China[2]Hebei Univ, Key Lab Pharmaceut Qual Control Hebei Prov, 180 WuSi Rd, Baoding 071002, Peoples R China[*1]School of Pharmaceutical Sciences & Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University. No. 180, WuSi Road, Baoding, 071002, PR China
通讯作者：
通讯机构：[1]Hebei Univ, Sch Pharmaceut Sci, 180 WuSi Rd, Baoding 071002, Peoples R China[2]Hebei Univ, Key Lab Pharmaceut Qual Control Hebei Prov, 180 WuSi Rd, Baoding 071002, Peoples R China[*1]School of Pharmaceutical Sciences & Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University. No. 180, WuSi Road, Baoding, 071002, PR China
推荐引用方式(GB/T 7714)：
Hu Liandong,Yang Chenchen,Kong Dongqian,et al.Development of a long-acting intramuscularly injectable formulation with nanosuspension of andrographolide[J].JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY.2016,35:327-332.doi:10.1016/j.jddst.2016.08.008.
APA：
Hu, Liandong,Yang, Chenchen,Kong, Dongqian,Hu, Qiaofeng,Gao, Na&Zhai, Fuxin.(2016).Development of a long-acting intramuscularly injectable formulation with nanosuspension of andrographolide.JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,35,
MLA：
Hu, Liandong,et al."Development of a long-acting intramuscularly injectable formulation with nanosuspension of andrographolide".JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY 35.(2016):327-332
