Single nucleotide polymorphisms (SNPs) in the Displacement-loop (D-loop) region of mitochondrial DNA have been reported to be associated with cancer risk in various types of cancer. To assess the frequency of D-loop SNPs in a large series of liposarcoma and establish correlations with cancer risk, we sequenced the D-loop of 82 liposarcoma patients and analyzed their use as predictive biomarkers for liposarcoma risk. The minor alleles of nucleotides 73G, 523-524del, 16,290T, 16,319A, 16,356C were associated with an increased risk for liposarcoma patients, whereas the insertion of C at the site 315 (located within the D310) were associated with a decreased risk for liposarcoma patients. These results suggest that SNPs in the mitochondrial D-loop should be considered as a biomarker which may be useful for the early detection of liposarcoma in individuals at risk of this cancer.
第一作者机构：[1]Hebei Med Univ, Hosp 4, Dept Osteol, Shijiazhuang 050011, Peoples R China[*1]Department of Osteology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, P.R. China
通讯作者：
通讯机构：[1]Hebei Med Univ, Hosp 4, Dept Osteol, Shijiazhuang 050011, Peoples R China[*1]Department of Osteology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, P.R. China
推荐引用方式(GB/T 7714)：
Xun Jianjun,Song Xiaolei,Gao Shejun,et al.Identification of sequence polymorphisms in the D-loop region of mitochondrial DNA as risk biomarker for liposarcoma[J].MITOCHONDRIAL DNA PART A.2016,27(5):3403-3404.doi:10.3109/19401736.2015.1018240.
APA：
Xun, Jianjun,Song, Xiaolei,Gao, Shejun,Yang, Huichai,Li, Zhenxing&Li, Linxing.(2016).Identification of sequence polymorphisms in the D-loop region of mitochondrial DNA as risk biomarker for liposarcoma.MITOCHONDRIAL DNA PART A,27,(5)
MLA：
Xun, Jianjun,et al."Identification of sequence polymorphisms in the D-loop region of mitochondrial DNA as risk biomarker for liposarcoma".MITOCHONDRIAL DNA PART A 27..5(2016):3403-3404
