机构：[1]Department of Medical Oncology, Fourth Hospital of HebeiMedical University, Shijiazhuang 050011, Hebei, China[2]College of Science and Technology, Yichang 443002, Hubei, China[3]Department of Pathology, Bethune International Peace Hospital, Shijiazhuang 050000, Hebei, China[4]Xingtai National Hospital, Xingtai 054000, Hebei, China
Interleukin-27 (IL-27) has been recognized as a pleiotropic cytokine with both pro- and anti-inflammatory properties. However, there are no data about the role of IL-27 polymorphism in the development of cervical cancer. A hospital-based case control study was conducted in 380 patients with cervical cancer and 380 healthy controls to investigate the possible associations of IL-27 gene polymorphisms (-964A/G, 29051/G, and 47301/C), with susceptibility to cervical cancer and clinical outcome. Our results suggested that the IL-27 29051/G was significantly associated with a decreased risk of cervical cancer (TG vs. IT, odds ratio (OR)=0.77; 95 % confidence interval (CI)=0.60-0.86; GG vs. TT, OR=0.95; 95 0 CI=0.72-0.96; TG+GG vs. TT, OR=0.87; 95 % CI=0.65-0.94). However, the genotype and allele frequencies of IL-27 (-964A/G and 47301/C) polymorphisms in cervical cancer patients were not significantly different from controls. Further analysis showed IL-27 2905T/G genotypes were associated with advanced tumor stages of cervical cancer patients. More interestingly, the IL-27 2905T/G genotypes were statistically significantly associated with the survival in cervical cancer patients. Our results showed that the IL-27 29051/G genotypes were associated with decreased susceptibility and development of cervical cancer in Chinese Han population.
第一作者机构：[1]Department of Medical Oncology, Fourth Hospital of HebeiMedical University, Shijiazhuang 050011, Hebei, China
通讯作者：
推荐引用方式(GB/T 7714)：
Shi Jian,Yuan Meng,Liu Shuang,et al.Correlation of IL-27 genetic polymorphisms with the risk and survival of cervical cancer in a Chinese Han population[J].TUMOR BIOLOGY.2016,37(5):6875-6879.doi:10.1007/s13277-015-4512-x.
APA：
Shi, Jian,Yuan, Meng,Liu, Shuang,Duan, Xiaoyang&Chen, Juan.(2016).Correlation of IL-27 genetic polymorphisms with the risk and survival of cervical cancer in a Chinese Han population.TUMOR BIOLOGY,37,(5)
MLA：
Shi, Jian,et al."Correlation of IL-27 genetic polymorphisms with the risk and survival of cervical cancer in a Chinese Han population".TUMOR BIOLOGY 37..5(2016):6875-6879
