Reprogrammed glucose metabolism is an emerging hallmark of cancer cells, which show a unique metabolic phenotype known as the Warburg effect. Lactate dehydrogenase A (LDHA), a key enzyme in the glycolytic process, executes the final step by conversion of lactate into pyruvate. However, little is known about the roles of LDHA in human glioblastoma (GBM). In this study, we aimed to determine the effects of LDHA and elucidate related underlying mechanisms. Data derived from Oncomine database showed that LDHA is commonly upregulated in GBM tissues in comparison with corresponding normal controls. Silencing of LDHA expression resulted in reduced glycolysis, decreased cell growth, increased cell apoptosis, and attenuated invasive ability. In the presence of 2-deoxyglucose, a glycolysis inhibitor, the oncogenic activities of LDHA were completely blocked. These findings provide evidence of the cellular functions of LDHA in the progression of GBM and suggest that LDHA might act as a potential therapeutic target for GBM treatment.
第一作者机构：[1]Hebei Med Univ, Hosp 4, Dept Radiotherapy 3, 12 Jiankang Rd, Shijiazhuang 050011, Peoples R China
通讯作者：
通讯机构：[1]Hebei Med Univ, Hosp 4, Dept Radiotherapy 3, 12 Jiankang Rd, Shijiazhuang 050011, Peoples R China[*1]The Third Department of Radiotherapy, The Fourth Hospital of Hebei Medical University, #12, Jiankang Road, Shijiazhuang 050011, China
推荐引用方式(GB/T 7714)：
Li Juan,Zhu Shuchai,Tong Jing,et al.Suppression of lactate dehydrogenase A compromises tumor progression by downregulation of the Warburg effect in glioblastoma[J].NEUROREPORT.2016,27(2):110-115.doi:10.1097/WNR.0000000000000506.
APA：
Li, Juan,Zhu, Shuchai,Tong, Jing,Hao, Hui,Yang, Jie...&Wang, Yuxiang.(2016).Suppression of lactate dehydrogenase A compromises tumor progression by downregulation of the Warburg effect in glioblastoma.NEUROREPORT,27,(2)
MLA：
Li, Juan,et al."Suppression of lactate dehydrogenase A compromises tumor progression by downregulation of the Warburg effect in glioblastoma".NEUROREPORT 27..2(2016):110-115
