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Magnesium prevents beta-glycerophosphate-induced calcification in rat aortic vascular smooth muscle cells

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WOS体系：
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收录情况： ◇ ESCI

作者：
Bai, Yaling[1] * ; Zhang, Junxia[1] ; Xu, Jinsheng[1,*1] ; Cui, Liwen[1] ; Zhang, Huiran[1] ; Zhang, Shenglei[1] ; Feng, Xunwei[1] ;
机构： [1]Hebei Med Univ, Hosp 4, Dept Nephrol, 12 Jiankang Rd, Shijiazhuang 050011, Hebei, Peoples R China
出处：
DOI： 10.3892/br.2015.473
ISSN：

关键词： magnesium phosphate vascular calcification vascular smooth muscle cells

摘要：
Vascular calcification (VC), in which high serum phosphate plays a critical role, is one major problem in patients with chronic kidney disease. Clinical studies report that magnesium has a protective effect on VC. However, the studies regarding the impact of high serum magnesium on VC at a cellular level are few and require further investigation. Therefore, the present study explored the effect of magnesium on calcification induced by beta-glycerophosphate (BGP) in rat aortic vascular smooth muscle cells (RAVSMCs). In the present study, the addition of magnesium decreased calcium deposition, which was increased by BGP. Higher magnesium levels inhibited BGP-induced alkaline phosphatase (ALP) activity and decreased the expression of core-binding factor alpha-1 (Cbf alpha 1). In conclusion, higher magnesium levels prevented BGP-induced calcification in RAVSMCs and inhibited the expression of Cbf alpha 1 and ALP. Thus, magnesium is influencing the expression of Cbf alpha 1 and ALP associated with VC and may have the potential to serve as a role for VC in clinical situations.

基金：
project of the Hebei Natural Science Fund [H2012206157]; project of the Hebei Major Medical Science [GL2011-51]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院分区：
出版当年[2015]版：
无
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 医学：研究与实验
JCR分区：
出版当年[2015]版：
无
最新[2023]版：
Q3 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 最新[2023版] 最新五年平均 出版当年[2015版] 出版当年五年平均 出版前一年[2014版]

第一作者：
第一作者机构： [1]Hebei Med Univ, Hosp 4, Dept Nephrol, 12 Jiankang Rd, Shijiazhuang 050011, Hebei, Peoples R China
通讯作者：
通讯机构： [1]Hebei Med Univ, Hosp 4, Dept Nephrol, 12 Jiankang Rd, Shijiazhuang 050011, Hebei, Peoples R China [*1]Department of Nephrology, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, Hebei 050011, P.R. China
推荐引用方式(GB/T 7714)：
Bai Yaling,Zhang Junxia,Xu Jinsheng,et al.Magnesium prevents beta-glycerophosphate-induced calcification in rat aortic vascular smooth muscle cells[J].BIOMEDICAL REPORTS.2015,3(4):593-597.doi:10.3892/br.2015.473.
APA：
Bai, Yaling,Zhang, Junxia,Xu, Jinsheng,Cui, Liwen,Zhang, Huiran...&Feng, Xunwei.(2015).Magnesium prevents beta-glycerophosphate-induced calcification in rat aortic vascular smooth muscle cells.BIOMEDICAL REPORTS,3,(4)
MLA：
Bai, Yaling,et al."Magnesium prevents beta-glycerophosphate-induced calcification in rat aortic vascular smooth muscle cells".BIOMEDICAL REPORTS 3..4(2015):593-597

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