机构:[1]Department of Thoracic Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China临床科室胸心外科(胸外科 心脏血管外科)河北医科大学第四医院[2]Department of Thoracic Surgery, The Third Hospital of Shijiazhuang, Shijiazhuang, China.
The aim of the study is to study the correlation of genetic polymorphism of vascular endothelial growth factor (VEGF) gene with susceptibility to primary lung cancer. A total of 414 patients with primary lung cancer and 338 healthy volunteers were enrolled in this case-control study from September 2008 to October 2011. Gene identification with PCR-RFLP (polymerase chain reaction-based restriction fragment length polymorphism) was used to detect in white blood cells from the subjects the single-nucleotide polymorphisms (SNP) of VEGF gene, including +405G/C, -460 T/C, -1154G/A, -2578C/A sites. Association of genotypes or haplotypes with susceptibility of lung cancer was analyzed with unconditional logistic regression adjusted by gender and age. Smoking was significantly associated with increased risk of lung cancer. Gene phenotypic analysis demonstrated that C allele of +405G/C in VEGF gene was significantly associated increased risk of lung cancer in males (P = 0.0094, odds ratio = 1.634.3), as that with carrying GCTC haplotype (odds ratio = 1.349), whereas carrying GACG had decreased risk for lung cancer (odds ratio = 0.044). No relationship existed between 460 T/C, -1154G/A, -2578C/A alleles of VEGF gene and risk of lung cancer. VEGF gene polymorphism may have a role in the development of lung cancer.
基金:
Hebei Natural Science Funding [C2009001199]
语种:
外文
被引次数:
WOS:
PubmedID:
中科院分区:
出版当年[2015]版:
大类|3 区医学
小类|3 区生物工程与应用微生物4 区遗传学4 区医学:研究与实验4 区肿瘤学
最新[2025]版:
大类|3 区医学
小类|3 区生物工程与应用微生物3 区遗传学3 区医学:研究与实验4 区肿瘤学
JCR分区:
出版当年[2015]版:
Q2MEDICINE, RESEARCH & EXPERIMENTALQ2GENETICS & HEREDITYQ2BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3ONCOLOGY
最新[2024]版:
Q1BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ1GENETICS & HEREDITYQ1MEDICINE, RESEARCH & EXPERIMENTALQ1ONCOLOGY
第一作者机构:[1]Department of Thoracic Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China
通讯作者:
通讯机构:[1]Department of Thoracic Surgery, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China[*1]Department of Thoracic Surgery, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang 050000, China
推荐引用方式(GB/T 7714):
Liu C.,Zhou X.,Gao F.,et al.Correlation of genetic polymorphism of vascular endothelial growth factor gene with susceptibility to lung cancer[J].CANCER GENE THERAPY.2015,22(6):312-316.doi:10.1038/cgt.2015.24.
APA:
Liu, C.,Zhou, X.,Gao, F.,Qi, Z.,Zhang, Z.&Guo, Y..(2015).Correlation of genetic polymorphism of vascular endothelial growth factor gene with susceptibility to lung cancer.CANCER GENE THERAPY,22,(6)
MLA:
Liu, C.,et al."Correlation of genetic polymorphism of vascular endothelial growth factor gene with susceptibility to lung cancer".CANCER GENE THERAPY 22..6(2015):312-316