机构：[1]Department of Gynecology and Obstetrics, Fourth Hospital of Hebei Medical University, Shijiazhuang, China河北医科大学第四医院[2]Department of Gynecology and Obstetrics, NO.3 People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201900, China[3]Research Center, Fourth Hospital of Hebei Medical University, Shijiazhuang, China河北医科大学第四医院科研中心医技科室[4]Department of General Surgery, Hebei General Hospital, Shijiazhuang, China and 5Department of pathology, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.河北医科大学第四医院[5]Department of pathology, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.病理科医技科室
We aimed to analyze the association between the distribution of dendritic cells (DC) with expression of tumor-infiltrating T lymphocytes and clinicopathologic parameters with prognosis in epithelial ovarian cancer (EOC). Thirty-three EOC patient samples were surgically resected, and pathology was examined for clinicopathological variables. Expression of S-100, CD1a, CD45RA and CD45RO was detected using the avidin-biotin complex immunohistochemical technique. The correlation of protein expression with surgical and pathological stage, histological grade, pathological type and prognosis was analyzed. There was significant difference in the CD45RA positive rate in early- and advanced-stage EOC with 50 and 10.5%, respectively (P < 0.05). Univariate analysis showed that CD45RO, histological grade and surgical-pathological staging were all factors that influenced the prognosis of patients with EOC. Higher survival rates were found in patients with harboring populations of CD1a(+) DC and CD45RO(+) T lymphocytes or populations of S-100(+) DC and CD45RO(+) T lymphocytes (P < 0.05). In addition, histological grade is related to cumulative survival rate. The higher degree of cell differentiation presented better outcome. In conclusion, EOC patients with populations of DC and CD45RO(+) T lymphocytes had a higher survival rate. Histological grade and surgical-pathological stage were independent factors affecting prognosis.
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外文
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中科院分区：
出版当年[2015]版：
大类|3 区医学
小类|3 区生物工程与应用微生物4 区遗传学4 区医学：研究与实验4 区肿瘤学
最新[2025]版：
大类|3 区医学
小类|3 区生物工程与应用微生物3 区遗传学3 区医学：研究与实验4 区肿瘤学
JCR分区：
出版当年[2015]版：
Q2MEDICINE, RESEARCH & EXPERIMENTALQ2GENETICS & HEREDITYQ2BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3ONCOLOGY
最新[2024]版：
Q1BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ1GENETICS & HEREDITYQ1MEDICINE, RESEARCH & EXPERIMENTALQ1ONCOLOGY
第一作者机构：[1]Department of Gynecology and Obstetrics, Fourth Hospital of Hebei Medical University, Shijiazhuang, China
通讯作者：
通讯机构：[3]Research Center, Fourth Hospital of Hebei Medical University, Shijiazhuang, China[*1]Research Center, Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang 050011, China.
推荐引用方式(GB/T 7714)：
Zhang Z.,Huang J.,Zhang C.,et al.Infiltration of dendritic cells and T lymphocytes predicts favorable outcome in epithelial ovarian cancer[J].CANCER GENE THERAPY.2015,22(4):198-206.doi:10.1038/cgt.2015.7.
APA：
Zhang, Z.,Huang, J.,Zhang, C.,Yang, H.,Qiu, H....&Shan, B..(2015).Infiltration of dendritic cells and T lymphocytes predicts favorable outcome in epithelial ovarian cancer.CANCER GENE THERAPY,22,(4)
MLA：
Zhang, Z.,et al."Infiltration of dendritic cells and T lymphocytes predicts favorable outcome in epithelial ovarian cancer".CANCER GENE THERAPY 22..4(2015):198-206
