Purpose: The aim of this study was to evaluate the salvage radiotherapy outcome in patients with local recurrent esophageal cancer after radical radiochemotherapy (RCT). Methods: A total of 114 patients with local recurrent esophageal squamous cell carcinoma after initial radical RCT were retrospectively analyzed. Fifty-five (55) patients belonged to the salvage radiotherapy group (SR group) and 59 patients to the non-salvage radiotherapy group (NSR group). Results: The median survival time after-recurrence was 4 months in all patients. The 1, 2, 3 year overall survival (OS) rates were 83.6%, 41.8% and 21.8% respectively in the SR group, and 57.6%, 16.9%, and 8.5% in the NSR group. The 6-month and 1-year survival rates after-recurrence were 41.8% and 16.4% respectively in the SR group, and 11.9% and 3.4% respectively in the NSR group. A salvage radiation dose > 50 Gy after initial radical RCT, improved the survival of patients with local recurrent esophageal cancer. Three patients (5.45%) from the SR group showed more than 3-grade radiation pneumonitis. In addition, esophageal fistula/perforation was observed in 11 cases (20.0%) in the SR group and in 8 cases (13.6%) in the NSR group. Conclusions: Salvage treatment after definitive RCT may improve the overall survival and survival after-recurrence of patients with local recurrent esophageal cancer.
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外文
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中科院分区:
出版当年[2015]版:
大类|3 区医学
小类|3 区核医学4 区肿瘤学
最新[2025]版:
大类|2 区医学
小类|2 区核医学3 区肿瘤学
JCR分区:
出版当年[2015]版:
Q2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ3ONCOLOGY
最新[2024]版:
Q1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ2ONCOLOGY
第一作者机构:[1]Peking Univ, Hosp 1, Dept Radiat Oncol, Beijing 100034, Peoples R China[2]Hebei Med Univ, Hosp 4, Dept Radiat Oncol, Shijiazhuang 050011, Hebei, Peoples R China
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推荐引用方式(GB/T 7714):
Zhou Zhi-guo,Zhen Chan-jun,Bai Wen-wen,et al.Salvage radiotherapy in patients with local recurrent esophageal cancer after radical radiochemotherapy[J].RADIATION ONCOLOGY.2015,10:doi:10.1186/s13014-015-0358-z.
APA:
Zhou, Zhi-guo,Zhen, Chan-jun,Bai, Wen-wen,Zhang, Ping,Qiao, Xue-ying...&Wang, Shuo-shuo.(2015).Salvage radiotherapy in patients with local recurrent esophageal cancer after radical radiochemotherapy.RADIATION ONCOLOGY,10,
MLA:
Zhou, Zhi-guo,et al."Salvage radiotherapy in patients with local recurrent esophageal cancer after radical radiochemotherapy".RADIATION ONCOLOGY 10.(2015)