机构：[1]Department of Obstetrics and Gynecology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China河北医科大学第四医院[2]Hebei Key Lab of Laboratory Animal Science, Hebei Medical University, Shijiazhuang, China[3]Department of Hematology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China临床科室血液内科河北医科大学第四医院[4]Department of Gynaecology Ultrasound, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China医技科室妇产超声科河北医科大学第四医院[5]Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China临床科室消化内科河北医科大学第四医院
MicroRNAs (miRNAs) can bind to the 3' untranslated regions (UTRs) of messenger RNAs, where they interfere with translation and thereby regulate cell differentiation, apoptosis, and tumorigenesis. Genetic polymorphisms in the 3' UTRs targeted by miRNAs alter the strength of miRNA binding in a manner that affects the behavior of individual miRNAs. In this study, four miRNA binding-site single nucleotide polymorphisms (SNPs) located in the 3' UTR of RYR3 (rs1044129), C14orf101 (rs4901706), KIAA0423 (rs1053667), and GOLGA7 (rs11337) were genotyped in non-Hodgkin lymphoma (NHL) patients to assess their relationships with cancer risk and overall survival. rs4901706, located in the 3' UTR of C14orf101, was shown to be independently related to overall survival in NHL patients by multivariate analysis (relative risk, 1.770; 95% Cl, 1.046-2.996; P = 0.033). The prognostic value of this SNP on tumor overall survival was supported in diffuse large B-cell lymphoma patients with a P value of 0.095 and validated in T-cell lymphoma patients with a P value of 0.037.
第一作者机构：[1]Department of Obstetrics and Gynecology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China
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推荐引用方式(GB/T 7714)：
Yang Bo,Liu Chao,Diao Lanping,et al.A polymorphism at the microRNA binding site in the 3 ' untranslated region of C14orf101 is associated with non-Hodgkin lymphoma overall survival[J].CANCER GENETICS.2014,207(4):141-146.doi:10.1016/j.cancergen.2014.03.007.
APA：
Yang, Bo,Liu, Chao,Diao, Lanping,Wang, Cuiju&Guo, Zhanjun.(2014).A polymorphism at the microRNA binding site in the 3 ' untranslated region of C14orf101 is associated with non-Hodgkin lymphoma overall survival.CANCER GENETICS,207,(4)
MLA：
Yang, Bo,et al."A polymorphism at the microRNA binding site in the 3 ' untranslated region of C14orf101 is associated with non-Hodgkin lymphoma overall survival".CANCER GENETICS 207..4(2014):141-146
