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Multiple MAGE-A genes as surveillance marker for the detection of circulating tumor cells in patients with ovarian cancer

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机构: [1]Department of Obstetrics and Gynecology, Bethune International Peace Hospital, Shijiazhuang, Hebei, People’s Republic of China [2]Tumor Research Institute, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China [3]Department of Regenerative Medicine, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Sugitani, Toyama, Japan
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关键词: Circulating tumor cells MAGE ovarian cancer surveillance marker

摘要:
Ovarian cancer is a leading cause of death among gynecologic malignancies. In this study, we reported the expression of melanoma-associated antigens A (MAGE-A) genes in peripheral blood from 80 patients with ovarian cancer and 30 healthy donors. MAGE-As expression was associated with the factors indicating poor prognosis. The expressions of MAGE-As and each individual MAGE-A genes were also associated with low overall survival of patients with ovarian cancer. Our results suggested MAGE-A genes may have the potential to be surveillance markers for the detection of circulating tumor cells and represent a poor prognosis for patients with ovarian cancer.

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基金编号: 81001178

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出版当年[2014]版:
大类 | 3 区 医学
小类 | 4 区 生物工程与应用微生物 4 区 毒理学
最新[2025]版:
大类 | 4 区 医学
小类 | 4 区 生物工程与应用微生物 4 区 毒理学
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出版当年[2014]版:
Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q3 TOXICOLOGY
最新[2024]版:
Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q4 TOXICOLOGY

影响因子: 最新[2024版] 最新五年平均 出版当年[2014版] 出版当年五年平均 出版前一年[2013版] 出版后一年[2015版]

第一作者:
第一作者机构: [1]Department of Obstetrics and Gynecology, Bethune International Peace Hospital, Shijiazhuang, Hebei, People’s Republic of China [2]Tumor Research Institute, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China
通讯作者:
通讯机构: [1]Department of Obstetrics and Gynecology, Bethune International Peace Hospital, Shijiazhuang, Hebei, People’s Republic of China [*1]Department of Obstetrics and Gynecology, Bethune International Peace Hospital, Shijiazhuang, Hebei 050082, People’s Republic of China
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