机构：[1]Departments of Nephrology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China,临床科室肾内科河北医科大学第四医院[2]Departments of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011. China.临床科室消化内科河北医科大学第四医院
The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) has been described in various types of cancers, and their association with cancer risk and disease outcome has been extensively identified. In the present study, we investigated the association between age-at-onset and SNPs in the mitochondrial D-loop using a population-based series of renal cell carcinoma(RCC). The SNP sites of nucleotides 16293A/G were identified for their association with age-at-onset using the log-rank test. The age-at-onset of patients with the minor allele G genotype was significantly lower than that of patients with the A genotype at the 16293 site (p < 0.001). Genetic polymorphisms in the D-loop are predictive markers of age-at-onset in RCC patients. Accordingly, the analysis of genetic polymorphisms in the mitochondrial D-loop may help identify RCC patient subgroups at high risk of early onset.
基金：
project of Hebei Natural Science Fund [H2012206157]
第一作者机构：[1]Departments of Nephrology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China,
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Xu Jinsheng,Guo Zhanjun,Zhang Junxia,et al.Single nucleotide polymorphisms in the mitochondrial displacement loop and age-at onset of renal cell carcinoma[J].SCIENTIFIC REPORTS.2013,3:doi:10.1038/srep02408.
APA：
Xu, Jinsheng,Guo, Zhanjun,Zhang, Junxia,Cui, Liwen,Zhang, Shenglei&Bai, Yaling.(2013).Single nucleotide polymorphisms in the mitochondrial displacement loop and age-at onset of renal cell carcinoma.SCIENTIFIC REPORTS,3,
MLA：
Xu, Jinsheng,et al."Single nucleotide polymorphisms in the mitochondrial displacement loop and age-at onset of renal cell carcinoma".SCIENTIFIC REPORTS 3.(2013)
