机构：[1]Department of Forensic Medicine, Hebei Key Laboratory of Forensic Medicine, Hebei Medical University, Shijiazhuang, 050017, Hebei Province, China.[2]Department of Thoracic, Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, Hebei Province, China河北医科大学第四医院胸五科临床科室[3]Laboratory Medical Science, School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjing, 212013, Jiangsu Province, China[4]Department of Medicinal Natural Product Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang, 050017, Hebei Province, China[5]Graduate School of Agricultural Science, Tohoku University, Aoba-ku, Sendai 981-8555, Japan.
Eight sesquiterpene lactones were isolated from the roots of Inula helenium and flowers of I. japonica. Among them, isoalantolactone (3) and santamarine (6) exhibited significant growth inhibitory activities against gynecologic cancer cell lines, while others weakly inhibited the growth of the cell lines (IC50 <= 100 mu m). In addition, 3 significantly inhibited the tumour growth of S180 tumour-bearing mice. Compounds 3 and 6 were not toxic to human embryonic lung fibroblast cells in vitro. These results demonstrated that the antitumour activities are closely related to the structures of the compounds, that is, an alpha-exomethylene-gamma-lactone ring is necessary for these activities.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81072551]; Key Project of Science & Technology of Hebei Province [11276103D-89]; Scientific Research Foundation for Returned Overseas Chinese Scholars of Hebei ProvinceScientific Research Foundation for the Returned Overseas Chinese Scholars [2006-02]; Scientific Research Foundation of Hebei Province [08B032, C2010000489]; Medical Research Foundation of the Health Department of Hebei Province [20090151]; Japan Society for the Promotion of ScienceMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of Science [19580120, 22580112]
第一作者机构：[1]Department of Forensic Medicine, Hebei Key Laboratory of Forensic Medicine, Hebei Medical University, Shijiazhuang, 050017, Hebei Province, China.[2]Department of Thoracic, Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, Hebei Province, China
通讯作者：
推荐引用方式(GB/T 7714)：
Li Yong,Ni Zhi-Yu,Zhu Meng-Chu,et al.Antitumour Activities of Sesquiterpene Lactones from Inula helenium and Inula japonica[J].ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES.2012,67(7-8):375-380.doi:10.1515/znc-2012-7-804.
APA：
Li, Yong,Ni, Zhi-Yu,Zhu, Meng-Chu,Dong, Mei,Wang, Si-Ming...&Cong, Bin.(2012).Antitumour Activities of Sesquiterpene Lactones from Inula helenium and Inula japonica.ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES,67,(7-8)
MLA：
Li, Yong,et al."Antitumour Activities of Sesquiterpene Lactones from Inula helenium and Inula japonica".ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES 67..7-8(2012):375-380
