机构：[1]Department of Pharmacy, Hebei University of Science and Technology. Yuhua East Road 70, Shijiazhuang 050018, P. R. China[2]Department of Pharmacology, Hebei Medical University. Zhongshan East Road 361, Shijiazhuang 050017, P. R. China[3]Department of CT, The Forth Hospital of Hebei Medical University. Jiankang Road 12, Shijiazhuang 050011, P. R. China医技科室CT磁共振科河北医科大学第四医院[4]Department of Pharmaceutics, New Drug Research and Development Center, North China Pharmaceutical Group Corporation. Heping East Road 388, Shijiazhuang 050015, P. R. China.
A novel drug delivery system of doxorubicin (DOX)-loaded Zein in situ gel for interstitial chemotherapy was investigated in this study. The possible mechanisms of drug release were described according to morphological analysis by optical microscopy and scanning electronic microscope (SEM). In vitro and in vivo anti-tumor activity studies showed that DOX-loaded Zein in situ gel was superior to DOX solution. Local pharmacokinetics in tumor tissue was studied by quantitative analysis with confocal laser scanning microscopy (CLSM) combined with microdialysis technology. A pharmacokinetics mathematical model of DOX-loaded Zein in situ gel in tumors was then built.
基金：
Natural Science Foundation of China (NSFC, 30801444), the
Natural Science Foundation of Hebei Province (C2009000693,
H2012208020) and the Hebei University of Science and Technology
Discipline Construction Office
第一作者机构：[1]Department of Pharmacy, Hebei University of Science and Technology. Yuhua East Road 70, Shijiazhuang 050018, P. R. China
通讯作者：
推荐引用方式(GB/T 7714)：
Cao Xiaoying,Geng Jianning,Su Suwen,et al.Doxorubicin-Loaded Zein in Situ Gel for Interstitial Chemotherapy[J].CHEMICAL & PHARMACEUTICAL BULLETIN.2012,60(10):1227-1233.doi:10.1248/cpb.c12-00270.
APA：
Cao, Xiaoying,Geng, Jianning,Su, Suwen,Zhang, Linan,Xu, Qian...&Gao, Zibin.(2012).Doxorubicin-Loaded Zein in Situ Gel for Interstitial Chemotherapy.CHEMICAL & PHARMACEUTICAL BULLETIN,60,(10)
MLA：
Cao, Xiaoying,et al."Doxorubicin-Loaded Zein in Situ Gel for Interstitial Chemotherapy".CHEMICAL & PHARMACEUTICAL BULLETIN 60..10(2012):1227-1233
