机构：[1]Department of Health Science, Kongju National University, Chungnam, Republic of Korea[2]Department of Anatomy and Neurobiology, Kagawa University, Kagawa, Japan[3]Department of Bioresource and Agrobiosciences, Kobe University, Kobe, Japan[4]Department of Anesthesiology and Perioperative Medicine, Kobe University, Kobe, Japan[5]Scientific Research Centre, Hebei Medical University Fourth Hospital, Hebei, China医技科室科研中心河北医科大学第四医院[6]Department of Forensic Medicine, Kagawa University, Kagawa, Japan[7]Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Hiroshima, Japan
Aims: This study was carried out to examine the effects of early postnatal maternal separation stress on the development of the cerebral cortex with respect to time-dependent fluctuations of neurotrophic factor ligand and receptor expression. Main methods: Wistar rats were separated from their mothers for 3 h per day during postnatal days (PND) 10 to 15. The cerebral cortex was analyzed by real-time RT-PCR for the evaluation of the expression of mRNA for brain-derived neurotrophic factor (BDNF), TrkB, insulin-like growth factor-1 (IGF-1), and type 1 IGF receptor (IGF-1R) on PND16, 20, 30, and 60. Key findings: The expression of these neurotrophic factor ligands and receptors in the cerebral cortex was enhanced on PND16 and PND20, and then it returned to baseline levels on PND30. By PND60, however, the expression levels were attenuated. Significance: The important implication of this study is the persistent abnormal fluctuation of neurotrophic factor expression for a prolonged period, triggered even after the brain growth spurt. Given that neurotrophic factors play important roles in brain development, it can be speculated that the altered expression of these factors induced by maternal separation may interrupt normal brain development and ultimately lead to functional disruption. However, the possibility of such changes leading to various functional disruptions and the underlying mechanisms involved require further study. (c) 2012 Elsevier Inc. All rights reserved.
基金：
Grant-in Aid for Scientific
Research from the Ministry of Education, Culture, Sports, Science
and Technology, Japan (C22591203).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院分区：
出版当年[2012]版：
大类|3 区医学
小类|3 区医学：研究与实验3 区药学
最新[2025]版：
大类|3 区医学
小类|2 区药学3 区医学：研究与实验
JCR分区：
出版当年[2012]版：
Q2MEDICINE, RESEARCH & EXPERIMENTALQ2PHARMACOLOGY & PHARMACY
最新[2023]版：
Q1MEDICINE, RESEARCH & EXPERIMENTALQ1PHARMACOLOGY & PHARMACY
第一作者机构：[1]Department of Health Science, Kongju National University, Chungnam, Republic of Korea[2]Department of Anatomy and Neurobiology, Kagawa University, Kagawa, Japan
通讯作者：
通讯机构：[2]Department of Anatomy and Neurobiology, Kagawa University, Kagawa, Japan[*1]Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University, 1750–1 Ikenobe, Miki-cho, Kagawa 761–0793, Japan.
推荐引用方式(GB/T 7714)：
Lee Kyoung-Youl,Miki Takanori,Yokoyama Toshifumi,et al.Neonatal repetitive maternal separation causes long-lasting alterations in various neurotrophic factor expression in the cerebral cortex of rats[J].LIFE SCIENCES.2012,90(15-16):578-584.doi:10.1016/j.lfs.2012.01.021.
APA：
Lee, Kyoung-Youl,Miki, Takanori,Yokoyama, Toshifumi,Ueki, Masaaki,Warita, Katsuhiko...&Takeuchi, Yoshiki.(2012).Neonatal repetitive maternal separation causes long-lasting alterations in various neurotrophic factor expression in the cerebral cortex of rats.LIFE SCIENCES,90,(15-16)
MLA：
Lee, Kyoung-Youl,et al."Neonatal repetitive maternal separation causes long-lasting alterations in various neurotrophic factor expression in the cerebral cortex of rats".LIFE SCIENCES 90..15-16(2012):578-584
