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p73 G4C14-to-A4T14 gene polymorphism and interaction with p53 exon 4 Arg72Pro on cancer susceptibility: a meta-analysis of the literature

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机构： [1]Institute of Hygiene, Universita` Cattolica del Sacro Cuore, Largo FrancescoVito 1, 00168 Rome, Italy, [2]Department of Preventive Medicine/Biostatisticsand Medical Decision Making, Nagoya University Graduate School ofMedicine, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, [3]Department of Epidemiology and Biostatistics, School of Public Health,Nanjing Medical University, 140 Hanzhong Rd., Nanjing 210029, China, [4]Department of Head and Neck Surgery, The University of Texas M. D.Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030,USA, [5]Department of Molecular Biology, Hebei Cancer Institute, HebeiMedical University, Fourth Hospital, Jiankanglu 12, Shijiazhuang 050011,China, [6]Division of Epidemiology and Prevention, Aichi Cancer CenterResearch Institute, 1-1, Kanokoden, Chikusa-ku, Nagoya, Aichi, 464-8681,Japan, [7]Department of Internal Medicine, Kyungpook National UniversityHospital, Samduk 2a 50, Daegu 700-412, Korea, [8]Molecular and HumanGenetics Division, Indian Institute of Chemical Biology, Council of Scientificand Industrial Research 4 Raja S. C. Mullick Road, Jadavpur, Kolkata–700 032,India, [9]Department of Epidemiology, The University of Texas M. D. AndersonCancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA, [10]HebeiCancer Institute and The Fourth Affiliated Hospital, Hebei Medical University,Jiankanglu 12, Shijiazhuang 050011, China [11]IRCCS San Raffaele Pisana,Via Val Cannuta s247, 00166 Rome, Italy.

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The p73 gene (1p36-33) is involved in cancer development through cell growth inhibition by inducing apoptosis in a p53-like manner. The p73 G4C14-to-A4T14 dinucleotide polymorphism, consisting of two single-nucleotide polymorphisms in the non-coding region of exon 2 that are in complete linkage disequilibrium, has been extensively studied in association with cancer risk. We performed a meta-analysis of published studies that examined the association between this p73 G4C14-to-A4T14 polymorphism and cancer by searching for relevant studies on Medline and Embase up to February 28, 2010. Pooling data from 19 case-control studies that included 6510 cancer cases and 5711 controls, we found that carriers of the p73 G4C14-to-A4T14 homozygous variant genotype (AT/AT) had an increased global risk of cancer [odds ratio (OR) = 1.30, 95% confidence interval (CI), 1.03-1.65]. There was no evidence of an effect modification of p73 AT/AT by age, gender, ethnicity or smoking status in subgroup analyses; however, a 1.35-fold statistically significant increased risk was found among individuals <55 years old. In case-only analysis, the homozygous p73 G4C14-to-A4T14 variant of p73 genotype was associated with the presence of the p53 exon 4 Arg72Pro allele (OR = 1.30, 95% CI, 1.02-1.64), which is suggestive of a biological interaction between the two genes in carcinogenesis. In conclusion, the p73 G4C14-to-A4T14 homozygous variant genotype might be a risk factor for cancer, especially in combination with the p53 exon 4 Arg72Pro polymorphism. Further studies looking at p73 G4C14-to-A4T14 and p53 exon 4 Arg72Pro interaction are required to support our findings.

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出版当年[2012]版：

大类 | 3 区生物

小类 | 2 区毒理学 3 区遗传学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区遗传学 4 区毒理学

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出版当年[2012]版：

Q1 TOXICOLOGY Q2 GENETICS & HEREDITY

最新[2023]版：

Q3 GENETICS & HEREDITY Q3 TOXICOLOGY

影响因子： 2.5 最新[2023版] 2.6 最新五年平均 3.5 出版当年[2012版] 3.714 出版当年五年平均 3.183 出版前一年[2011版] 3.497 出版后一年[2013版]

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第一作者机构： [1]Institute of Hygiene, Universita` Cattolica del Sacro Cuore, Largo FrancescoVito 1, 00168 Rome, Italy,

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通讯机构： [1]Institute of Hygiene, Universita` Cattolica del Sacro Cuore, Largo FrancescoVito 1, 00168 Rome, Italy, [11]IRCCS San Raffaele Pisana,Via Val Cannuta s247, 00166 Rome, Italy.

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