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Long Noncoding RNA High Expression in Hepatocellular Carcinoma Facilitates Tumor Growth Through Enhancer of Zeste Homolog 2 in Humans

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机构: [1]Department of Medical Genetics, Second Military Medical University, Shanghai, China [2]The Third Department of Hepatic Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, China [3]The Second Department of Hepatic Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, China [4]Department of Laboratory Medicine, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, China [5]Department of Hepatobiliary Surgery, Hebei Cancer Hospital, Hebei Medical University, Hebei, China.
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In recent years, long noncoding RNAs (lncRNAs) have been shown to have critical regulatory roles in cancer biology. However, the contributions of lncRNAs to hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) remain largely unknown. Differentially expressed lncRNAs between HBV-related HCC and paired peritumoral tissues were identified by microarray and validated using quantitative real-time polymerase chain reaction. Liver samples from patients with HBV-related HCC were analyzed for levels of a specific differentially expressed lncRNA High Expression In HCC (termed lncRNA-HEIH); data were compared with survival data using the Kaplan-Meier method and compared between groups by the log-rank test. The effects of lncRNA-HEIH were assessed by silencing and overexpressing the lncRNA in vitro and in vivo. The expression level of lncRNA-HEIH in HBV-related HCC is significantly associated with recurrence and is an independent prognostic factor for survival. We also found that lncRNA-HEIH plays a key role in G(0)/G(1) arrest, and further demonstrated that lncRNA-HEIH was associated with enhancer of zeste homolog 2 (EZH2) and that this association was required for the repression of EZH2 target genes. Conclusions: Together, these results indicate that lncRNA-HEIH is an oncogenic lncRNA that promotes tumor progression and leads us to propose that lncRNAs may serve as key regulatory hubs in HCC progression. (HEPATOLOGY 2011;54:1679-1689)

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基金编号: 81071680 30671920 2008ZX10002-018 2008ZX10002-025

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出版当年[2011]版:
大类 | 1 区 医学
小类 | 1 区 胃肠肝病学
最新[2025]版:
大类 | 1 区 医学
小类 | 1 区 胃肠肝病学
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出版当年[2011]版:
Q1 GASTROENTEROLOGY & HEPATOLOGY
最新[2024]版:
Q1 GASTROENTEROLOGY & HEPATOLOGY

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第一作者机构: [1]Department of Medical Genetics, Second Military Medical University, Shanghai, China
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