Doxorubicin and galactose were chemically conjugated to dextran by the carboxypropyl spacers and the conjugate was formulated into nanoparticle with free doxorubicin. The content of doxorubicin was as high as 17.2% in the nanoscale drug delivery systems (nano-DDSs) and the nanoparticle size was less than 190 nm. In an in vitro cytotoxicity experiment, the nano-DDSs had higher cytotoxicity than free DOX against the drug resistant HepG2 cells. In a human tumor xenograft nude mouse model, the nano-DDSs generated higher therapeutic effect than free doxorubicin. These promising data show a better anti-tumor efficacy on drug resistant HepG2 cells of nano-DDSs versus free doxorubicin, and warrant further studies in both animals and humans.
第一作者机构：[1]Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Cao Yu,Gu Ying,Liu Lina,et al.Reversion of Multidrug Resistance Using Self-Organized Nanoparticles Holding Both Doxorubicin and Targeting Moiety[J].LETTERS IN DRUG DESIGN & DISCOVERY.2010,7(7):500-506.doi:10.2174/157018010791526322.
APA：
Cao, Yu,Gu, Ying,Liu, Lina,Yang, Yi,Zhao, Peiguang...&Yang, Changjiang.(2010).Reversion of Multidrug Resistance Using Self-Organized Nanoparticles Holding Both Doxorubicin and Targeting Moiety.LETTERS IN DRUG DESIGN & DISCOVERY,7,(7)
MLA：
Cao, Yu,et al."Reversion of Multidrug Resistance Using Self-Organized Nanoparticles Holding Both Doxorubicin and Targeting Moiety".LETTERS IN DRUG DESIGN & DISCOVERY 7..7(2010):500-506
