机构：[1]Research Center, the Fourth Clinical Hospital of Hebei Medical University and Hebei Cancer Institute, 12 Jiankanglu, Shijiazhuang, 050011, China临床科室河北省肿瘤研究所河北医科大学第四医院[2]Department of Pathology, the Fourth Clinical Hospital of Hebei Medical University, Shijiazhuang, China
Current strategies for cancer gene therapy consist mainly of direct inhibition of tumor cell growth and activation of systemic host defense mechanisms. Cytokine gene-transduced tumor cells have been used as vaccines in clinical trials, which have shown good safety profiles and some local responses but substantial lack of systemic efficacy. Cytokines should be directed at the level of gene selection and delivery, in order to identify the optimal cytokine and achieve efficient and durable cytokine expression at the level of improving immune stimulation. In this review, we will summarize the current achievements of cytokine gene therapy, especially viral-vector, and their applications in cancer treatment. Additionally, we will also discuss and propose future perspectives about cancer gene therapy. (C) 2010 Elsevier Ltd. All rights reserved.
第一作者机构：[1]Research Center, the Fourth Clinical Hospital of Hebei Medical University and Hebei Cancer Institute, 12 Jiankanglu, Shijiazhuang, 050011, China
通讯作者：
通讯机构：[1]Research Center, the Fourth Clinical Hospital of Hebei Medical University and Hebei Cancer Institute, 12 Jiankanglu, Shijiazhuang, 050011, China
推荐引用方式(GB/T 7714)：
Liu Lihua,Wang Shijie,Shan Baoen,et al.Advances in viral-vector systemic cytokine gene therapy against cancer[J].VACCINE.2010,28(23):3883-3887.doi:10.1016/j.vaccine.2010.03.041.
APA：
Liu, Lihua,Wang, Shijie,Shan, Baoen,Sang, Meixiang,Liu, Shuang&Wang, Guiying.(2010).Advances in viral-vector systemic cytokine gene therapy against cancer.VACCINE,28,(23)
MLA：
Liu, Lihua,et al."Advances in viral-vector systemic cytokine gene therapy against cancer".VACCINE 28..23(2010):3883-3887
