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The Functional Polymorphisms on Promoter Region of Matrix Metalloproteinase-12,-13 Genes May Alter the Risk of Epithelial Ovarian Carcinoma in Chinese

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机构: [1]Department of Molecular Biology, Hebei Cancer Institute, Shijiazhuang, China [2]Department of Obstetrics and Gynaecology, Hebei Medical University, Fourth Hospital
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关键词: Epithelial ovarian carcinoma MMP-12 MMP-13 Single nucleotide polymorphism Risk

摘要:
Backgrounds and Aims: Growing evidences indicate that single nucleotide polymorphisms (SNPs) of matrix metalloproteinases (MMPs) gene promoter may alter MMPs protein expression levels to influence malignant turners developing and progressing. Our Study was to assess the effects of the SNPs in the promoter region of MMP-12 and MMP-13 oil the risk of epithelial ovarian carcinoma (EOC) developing and progressing. Methods: MMP-12 A-82G and MMP-13 A-77G SNPs were genotyped by polymerase chain reaction-restriction fragment length polymorphism in 256 EOC patients and 329 controls. Results: The A/G genotype frequency of MMP-12 was significantly higher in patients than in controls (7.0% vs 3.3%, P = 0.04), similarly, the frequently of MMP-12 82G allele was higher in patients too (P - 0.04). Compared with A/A genotype, A/G genotype significantly increased the risk of EOC (odds ratio, 2.19; 95% confidence interval, 1.01-4.72). Age-stratified analysis showed that individuals with A/G genotype had a higher risk in the final diagnosis aged younger than 50 years. We observed no overall association between MMP-13-77A/G polymorphism and EOC. However, in elevated positive association was observed for A/A versus G/G + A/G genotypes in mucinous ovarian cancer. Combining the analyzed 2 SNPs, the haplotype distributions in patients were not significantly different from that in controls. Conclusion: These results suggested that the G allele of the MMP-12 82A/G polymorphism might be a risk factor for the development and progression of EOC and that the A/A genotype of MMP-/3-77A/G polymorphism was associated with special pathological subtype and clinical stage in EOC at least in Chinese women.

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中科院分区:
出版当年[2009]版:
大类 | 4 区 医学
小类 | 4 区 妇产科学 4 区 肿瘤学
最新[2025]版:
大类 | 3 区 医学
小类 | 3 区 妇产科学 3 区 肿瘤学
JCR分区:
出版当年[2009]版:
Q2 OBSTETRICS & GYNECOLOGY Q3 ONCOLOGY
最新[2024]版:
Q1 OBSTETRICS & GYNECOLOGY Q1 ONCOLOGY

影响因子: 最新[2024版] 最新五年平均 出版当年[2009版] 出版当年五年平均 出版前一年[2008版] 出版后一年[2010版]

第一作者:
第一作者机构: [1]Department of Molecular Biology, Hebei Cancer Institute, Shijiazhuang, China [*1]Department of Molecular Biology, Hebei Cancer Institute, Hebei Medical University, Fourth Hospital, Jiankanglu 12, Shijiazhuang 050011, China.
通讯作者:
通讯机构: [1]Department of Molecular Biology, Hebei Cancer Institute, Shijiazhuang, China [*1]Department of Molecular Biology, Hebei Cancer Institute, Hebei Medical University, Fourth Hospital, Jiankanglu 12, Shijiazhuang 050011, China.
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