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Methylation of CLDN6, FBN2, RBP1, RBP4, TFP12, and TMEFF2 in esophageal squamous cell carcinoma

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收录情况： ◇ SCIE

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机构： [1]Univ Adelaide, Discipline Surg, Adelaide, SA 5005, Australia [2]Kyoto Univ, Grad Sch Med, Dept Surg, Sakyo Ku, Kyoto 6068507, Japan [3]Hebei Med Univ, Hosp 4, Dept Thorac Surg, Shijiazhuang 050011, Hebei, Peoples R China [4]Flinders Univ S Australia, Sch Nursing & Midwifery, Bedford Pk, SA 5042, Australia

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关键词： esophageal cancer methylation CLDN6 FPP42 RBP1 RBP4 TFPI2 TMEFF2

摘要：

In the development and progression of cancer, tumor suppressor genes may be silenced by mechanisms such as methylation. Thus the discovery of new genes silenced by methylation may uncover new tumor suppressor genes, and improve our understanding of cancer biology. In this study we investigated the methylation of 19 genes in esophageal squamous cell carcinoma. Methylation was measured in 10 of these genes in esophageal squamous cell carcinoma cell lines: CDH13, CLDN6, C16orf62, FBN2, FNBP1, ID4, RBP1, RBP4, TFPI2 and TMEFF2. To determine if there was a correlation between DNA methylation and gene silencing, each cell line was cultured with or without the demethylating drug 5-aza-2'-deoxycytidine (aza-dC). For 6 genes (CLDN6, FBN2, RBP1, RBP4, TFPI2 and TMEFF2) there was an association between reduction of methylation and increase in mRNA expression in the demethylated cell lines. The frequency of the methylation of these 6 genes in esophageal squamous cell carcinoma resection specimens was also investigated. All 6 genes showed more frequent methylation in the tumor than the matched proximal resection margin of uninvolved esophagus. There was a significant difference in the frequency of methylation and in the extent of the methylation between the cancer and the margin tissues for CLDN6, FBN2, TFPI2 and TMEFF2 (P=0.0007, P=0.0048 P=0.0002 and P<0.0001, respectively). This is the first report of gene silencing by methylation of CLDN6, FBN2, RBP4, TFPI2 and TMEFF2 in esophageal squamous cell carcinoma.

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基金编号： 275504

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出版当年[2009]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

最新[2025]版：

大类 | 3 区医学

小类 | 4 区肿瘤学

JCR分区：

出版当年[2009]版：

Q3 ONCOLOGY

最新[2024]版：

Q2 ONCOLOGY

影响因子： 3.9 最新[2024版] 3.5 最新五年平均 1.588 出版当年[2009版] 1.641 出版当年五年平均 1.524 出版前一年[2008版] 1.686 出版后一年[2010版]

第一作者：

第一作者机构： [1]Univ Adelaide, Discipline Surg, Adelaide, SA 5005, Australia [2]Kyoto Univ, Grad Sch Med, Dept Surg, Sakyo Ku, Kyoto 6068507, Japan [*1]Discipline of Surgery, The University of Adelaide, Adelaide, South Australia 5005, Australia

通讯作者：

通讯机构： [1]Univ Adelaide, Discipline Surg, Adelaide, SA 5005, Australia [2]Kyoto Univ, Grad Sch Med, Dept Surg, Sakyo Ku, Kyoto 6068507, Japan [*1]Discipline of Surgery, The University of Adelaide, Adelaide, South Australia 5005, Australia

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