We defined the maximum-tolerated dose (MTD) of chemoradiotherapy (cisplatin (CDDP) with 5-fluorouracil (5-FU) and concurrent chemoradiotherapy) for Chinese patients with esophageal cancer. Twenty-one previously untreated patients with primary esophageal cancer were entered into this study. Escalating doses of CDDP with 5-FU were administered in a modified Fibonacci sequence, with concurrent conventional fractionation radiotherapy (CFR) of 60 Gy or 50 Gy. The starting doses were CDDP 37.5 mg/m(2) on day 1, and 5-FU 500 mg/m(2) on days 1-5, respectively. The regimen was repeated 4 times every 28 days. If no dose-limiting toxicity (DLT) was observed, the next dose level was applied. The procedures were repeated until DLT appeared. The MTD was declared to be 1 dose level below the level at which DLT appeared. DLT was grade 3 radiation-induced esophagitis at a dose level of CDDP 60 mg/m(2) with 5-FU 700 mg/m(2) and concurrent 60 Gy CFR. MTD was defined as CDDP 52.5 mg/m(2) with 5-FU 700 mg/m(2) and concurrent 50 Gy CFR. The MTD of CDDP with 5-FU and in concurrent chemoradiotherapy for Chinese patients with esophageal cancer is CDDP 52.5 mg/m(2) on day 1 and 5FU 700 mg/m(2) on days 1-5, repeated 4 times every 28 days, and concurrent 50 Gy CFR. Further evaluation of this regimen in a prospective phase II trial is ongoing.
第一作者机构:[1]Hebei Med Univ Fourth Hosp, Dept Radiat Oncol 1, Shijiazhuang 050011, Peoples R China[3]N China Petr Bur Gen Hosp, Dept Oncol, Renqiu 062552, Peoples R China
通讯作者:
通讯机构:[1]Hebei Med Univ Fourth Hosp, Dept Radiat Oncol 1, Shijiazhuang 050011, Peoples R China[2]Beijing Univ, Hosp 1, Dept Radiat Oncol, Beijing 10034, Peoples R China
推荐引用方式(GB/T 7714):
Lin Qiang,Gao Xian-Shu,Qiao Xue-Ying,et al.Phase I trial of escalating-dose cisplatin with 5-fluorouracil and concurrent radiotherapy in Chinese patients with esophageal cancer[J].ACTA MEDICA OKAYAMA.2008,62(1):37-44.doi:10.18926/AMO/30984.
APA:
Lin, Qiang,Gao, Xian-Shu,Qiao, Xue-Ying,Zhou, Zhi-Guo,Zhang, Ping...&Asaumi, Junichi.(2008).Phase I trial of escalating-dose cisplatin with 5-fluorouracil and concurrent radiotherapy in Chinese patients with esophageal cancer.ACTA MEDICA OKAYAMA,62,(1)
MLA:
Lin, Qiang,et al."Phase I trial of escalating-dose cisplatin with 5-fluorouracil and concurrent radiotherapy in Chinese patients with esophageal cancer".ACTA MEDICA OKAYAMA 62..1(2008):37-44