机构：[1]Department of Pharmaceutics, Shenyang Pharmaceutical University, WenhuaRoad 103, Shenyang 110016[2]Department of Stomatology, The Fourth Hospital of Hebei Medical University, Jiankang Road 12, Shijiazhuang 050011临床科室口腔科河北医科大学第四医院[3]New Drug Research and Development Center, North China Pharmaceutical Group Corporation, Heping East Road 388, Shijiazhuang 050015, P.R. China
The aim of this study is to investigate the expression of matrix metal loproteinase 2 (MMP-2) and the tissue inhibitor of metal loproteinase 2 (TIMP-2) in oral squamous cell carcinoma (OSCC) and adjacent normal tissues, and explore the role of MMP-2 and TIMP-2 in carcinoma metastasis and invasion. Expression of MMP-2 and TIMP-2 was evaluated in 40 cases with semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR) and immunohistochemical techniques. The values of MMP-2/ beta-actin and TIMP-2/beta-actin in OSCC were significantly higher than those in adjacent normal tissues 2 cm and >= 5 cm from carcinoma tissues (p < 0.05). The results of immuno-histochernical analysis show that the positive expression of MMP-2 and TIMP-2 protein in tumor tissues (60.0 and 52.5%) was higher than that in adjacent normal tissues 2 cm (30.0 and 22.5%) and 5 cm (22.5 and 25.0%) from cancer tissues, and the difference was significant (p < 0.05). The expression of MMP-2 and TIMP-2 was related to the differentiation degree of tumor cells, metastatic lymph node status and stage of carcinoma, but not related to the age and gender of patients, or location of the carcinoma. Therefore, MMP-2 and TIMP-2 may play important roles in the invasion and metastasis of OSCC.
第一作者机构：[1]Department of Pharmaceutics, Shenyang Pharmaceutical University, WenhuaRoad 103, Shenyang 110016
通讯作者：
通讯机构：[1]Department of Pharmaceutics, Shenyang Pharmaceutical University, WenhuaRoad 103, Shenyang 110016[*1]Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, P.R. China
推荐引用方式(GB/T 7714)：
Gao ZB,Duan YQ,Zhang L,et al.Expression of matrix metalloproteinase 2 and its tissue inhibitor in oral squamous cell carcinoma[J].INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE.2005,16(4):599-603.doi:10.3892/ijmm.16.4.599.
APA：
Gao, ZB,Duan, YQ,Zhang, L,Chen, DW&Ding, PT.(2005).Expression of matrix metalloproteinase 2 and its tissue inhibitor in oral squamous cell carcinoma.INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,16,(4)
MLA：
Gao, ZB,et al."Expression of matrix metalloproteinase 2 and its tissue inhibitor in oral squamous cell carcinoma".INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 16..4(2005):599-603
