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ZEB1-Mediated Transcriptional Upregulation of circWWC3 Promotes Breast Cancer Progression through Activating Ras Signaling Pathway.

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Pubmed体系：

收录情况： ◇ SCIE

作者：
Meng Lingjiao[1] * ; Liu Sihua[1] * ; Liu Fei[1] * ; Sang Meijie[1,2] * ; Ju Yingchao[3] ; Fan Xiaojie[1,4] ; Gu Lina[1,5] ; Li Ziyi[1] ; Geng Cuizhi[6,*2] ; Sang Meixiang[1,5,*1] ;
机构： [1]Research Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China [2]Department of Surgical Nursing, Hebei University of Chinese Medicine, Xingyuan Road, Shijiazhuang, Hebei 050200, P.R. China [3]Animal Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China [4]Pathology Department, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China [5]Key Laboratory for Tumor Diagnosis, Prevention and Therapy in Hebei Province, Shijiazhuang, Hebei 050017, P.R. China [6]Breast Diagnostic and Therapeutic Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China
出处：
DOI： 10.1016/j.omtn.2020.08.015
ISSN：

摘要：
Zinc finger E-box binding homeobox 1 (ZEB1) has been widely recognized as an important driver of tumor growth and metastasis. However, nothing is known about ZEB1-regulated circular (circ)RNAs in cancer. In the current study, we evaluated the function of a novel ZEB1-regulated circRNA derived from the WWC3 gene locus, circWWC3 in breast cancer progression. We found that ZEB1 upregulated circWWC3 expression but not the linear WWC3 mRNA expression. circWWC3 is highly expressed in breast cancer tissues and is associated with the poor prognosis of breast cancer patients. Silencing of circWWC3 significantly suppresses the proliferation, migration, and invasion of breast cancer cells. Mechanically, circWWC3 upregulates multiple oncogenes' expression of the Ras signaling pathway through acting as the sponge of microRNA (miR)-26b-3p and miR-660-3p. Moreover, short hairpin (sh)RNA-mediated knockdown of circWWC3 partially antagonized ZEB1-mediated breast cancer growth and metastasis in vivo. Our findings reveal that ZEB1-mediated upregulation of circWWC3 promotes breast cancer progression through activating Ras signaling pathway, which provides a potential therapeutic target and prognostic biomarker for breast cancer. Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

基金：
National Nature Science Foundation of China (number 81972722).
语种：
外文
被引次数：
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PubmedID：
中科院分区：
出版当年[2020]版：
大类 | 2 区 医学
小类 | 2 区 医学：研究与实验
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 医学：研究与实验
JCR分区：
出版当年[2020]版：
Q1 MEDICINE, RESEARCH & EXPERIMENTAL
最新[2024]版：
Q1 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 最新[2024版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]Research Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China
共同第一作者：
通讯作者：
通讯机构： [1]Research Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China [5]Key Laboratory for Tumor Diagnosis, Prevention and Therapy in Hebei Province, Shijiazhuang, Hebei 050017, P.R. China [6]Breast Diagnostic and Therapeutic Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China [*1]Research Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China [*2]Breast Diagnostic and Therapeutic Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China.
推荐引用方式(GB/T 7714)：
Meng Lingjiao,Liu Sihua,Liu Fei,et al.ZEB1-Mediated Transcriptional Upregulation of circWWC3 Promotes Breast Cancer Progression through Activating Ras Signaling Pathway.[J].MOLECULAR THERAPY-NUCLEIC ACIDS.2020,22:124-137.doi:10.1016/j.omtn.2020.08.015.
APA：
Meng Lingjiao,Liu Sihua,Liu Fei,Sang Meijie,Ju Yingchao...&Sang Meixiang.(2020).ZEB1-Mediated Transcriptional Upregulation of circWWC3 Promotes Breast Cancer Progression through Activating Ras Signaling Pathway..MOLECULAR THERAPY-NUCLEIC ACIDS,22,
MLA：
Meng Lingjiao,et al."ZEB1-Mediated Transcriptional Upregulation of circWWC3 Promotes Breast Cancer Progression through Activating Ras Signaling Pathway.".MOLECULAR THERAPY-NUCLEIC ACIDS 22.(2020):124-137

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