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Matrine promotes hepatic oval cells differentiation into hepatocytes and alleviates liver injury by suppression of Notch signalling pathway.

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Shi Jianfei[1] * ; Han Guangjie[1] ; Wang Jinfeng[1] ; Han Xin[1] ; Zhao Man[1] ; Duan Xiaoling[1] ; Mi Lili[1] ; Li Ning[1] ; Yin Xiaolei[1] ; Shi Huacun[1] ; Li Cuizhen[1] ; Xu Jinsheng[2,*1] ; Yin Fei[1,*2] ;
机构： [1]Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, ShiJiaZhuang, PR China [2]Department of Nephrology, The Fourth Hospital of Hebei Medical University, ShiJiaZhuang, PR China
出处：
DOI： 10.1016/j.lfs.2020.118354
ISSN：

关键词： Matrine Hepatic oval cells (HOCs) Notch signalling pathway Hepatocellular carcinoma (HCC) Cirrhosis Rat Solt-Farber model Differentiation

摘要：
Recent studies have shown that the hyperactive Notch pathway is involved in cirrhosis and hepatocellular carcinoma (HCC) development by regulating differentiation of hepatic oval cells (HOCs) into cancer cells. The aim of this study was to investigate whether matrine can alleviate liver injury and promote HOC differentiation into hepatocytes by suppression of Notch pathway. We evaluated the expression of Notch-1, Jagged-1, and Hes-1 in HCC tissue by immunohistochemistry. Stem cell characteristics of HOCs were evaluated by CCK-8, cell cycle, and apoptosis. The expression of Notch pathway, HOC markers and albumin (ALB) was detected by immunohistochemistry, QRT-PCR and western blotting. The effects of matrine in protecting liver in vivo were investigated in a rat Solt-Farber precancerous model. We found an abnormal activated Notch pathway in HCC tissue, and the hyperactive Notch pathway was strongly associated with poor liver function in patients with cirrhosis with HCC. Using siNotch-1 to inhibit Notch pathway confirmed that Notch pathway could maintain stem cell characteristics of HOCs. Matrine inhibited stem cell characteristics of HOCs, the expression of Notch pathway and HOC markers but upregulated ALB. Matrine in combined with siNotch-1 RNA decreased the more potently inhibited HOC markers and Notch pathway. In rat Solt-Farber precancerous model, prophylactic application of matrine alleviated liver injury, downregulated Notch pathway and HOC markers, and upregulated ALB in a dose-dependent manner. Matrine could promote the differentiation of HOCs into hepatocytes by inhibiting the Notch signalling pathway and alleviate liver injury. Copyright © 2020 Elsevier Inc. All rights reserved.

基金：
National Natural Science Foundation of China (grant number: 81072966/H2902). Medical science research key project of Hebei Provincial Health and Family Planning Commission of China (grant no. 20201062).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院分区：
出版当年[2020]版：
大类 | 3 区 医学
小类 | 3 区 医学：研究与实验 3 区 药学
最新[2025]版：
大类 | 3 区 医学
小类 | 2 区 药学 3 区 医学：研究与实验
JCR分区：
出版当年[2020]版：
Q1 PHARMACOLOGY & PHARMACY Q2 MEDICINE, RESEARCH & EXPERIMENTAL
最新[2024]版：
Q1 MEDICINE, RESEARCH & EXPERIMENTAL Q1 PHARMACOLOGY & PHARMACY

影响因子： 最新[2024版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, ShiJiaZhuang, PR China
通讯作者：
通讯机构： [1]Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, ShiJiaZhuang, PR China [2]Department of Nephrology, The Fourth Hospital of Hebei Medical University, ShiJiaZhuang, PR China [*1]Department of Nephrology, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang, Hebei 050019, PR China. [*2]Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, No. 12, Jiankang Road, Shijiazhuang, Hebei 050019, PR China
推荐引用方式(GB/T 7714)：
Shi Jianfei,Han Guangjie,Wang Jinfeng,et al.Matrine promotes hepatic oval cells differentiation into hepatocytes and alleviates liver injury by suppression of Notch signalling pathway.[J].LIFE SCIENCES.2020,261:doi:10.1016/j.lfs.2020.118354.
APA：
Shi Jianfei,Han Guangjie,Wang Jinfeng,Han Xin,Zhao Man...&Yin Fei.(2020).Matrine promotes hepatic oval cells differentiation into hepatocytes and alleviates liver injury by suppression of Notch signalling pathway..LIFE SCIENCES,261,
MLA：
Shi Jianfei,et al."Matrine promotes hepatic oval cells differentiation into hepatocytes and alleviates liver injury by suppression of Notch signalling pathway.".LIFE SCIENCES 261.(2020)

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