Polymorphisms of the DNA repair gene XPA and XPC and its correlation with gastric cardiac adenocarcinoma in a high incidence population in North China.
机构：[1]Department of Pathology, Hebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.临床科室医技科室河北省肿瘤研究所病理科河北医科大学第四医院[2]Department of Molecular biology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China医技科室分子生物学室河北医科大学第四医院[3]Department of Endoscope, Hebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.临床科室医技科室河北省肿瘤研究所内镜科河北医科大学第四医院
Investigated the association of DNA repair gene xeroderma pigmentosum group A(XPA) and C(XPC) polymorphisms with the risk of gastric cardiac adenocarcinoma (GCA) in a high incidence region in north China.
Polymorphisms of a number of DNA repair genes may contribute to variations in DNA repair capacity and genetic susceptibility to different cancers.
Two single nucleotide polymorphisms of XPA and 3 single nucleotide polymorphisms of XPC were genotyped in 253 GCA patients and 612 healthy controls.
Family history of upper gastrointestinal cancer may increase the risk of developing GCA. Compared with A/A genotype, A/G+G/G genotype of XPA A23G significantly decreased the risk of developing GCA especially in nonsmoker group. The genotype and allelotype distributions of XPC intron 9 PAT+/- and exon 15 Lys939Gln in GCA patients were not significantly different from that in healthy controls (P>0.05). T allelotype frequencies of XPC exon 8 Val499Ala in GCA patients was significantly lower than that in healthy controls (P<0.05). The C/T genotype frequency of XPC exon 8 in GCA patients (35.6%) was significantly different from that in healthy controls (46.1%) (P=0.01). Compared with individuals with C/C genotype, individuals with T allele (C/T or T/T genotype) had significantly lower risk in developing GCA. We also found that polymorphisms of this 3 XPC locus were in linkage disequilibrium.
XPA A23G and XPC exon 8 Val499Ala polymorphisms may be useful markers for identifying individuals at risk of developing GCA in the high incidence region of north China.
基金：
considerable Distinctive subjects
foundation of Hebei province.
语种：
外文
PubmedID：
中科院分区：
出版当年[2008]版：
大类|3 区医学
小类|3 区胃肠肝病学
最新[2025]版：
大类|3 区医学
小类|4 区胃肠肝病学
第一作者：
第一作者机构：[1]Department of Pathology, Hebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
通讯作者：
通讯机构：[3]Department of Endoscope, Hebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.[*1]Hebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Jiankang Road 12, Shijiazhuang 050011, Hebei, China
推荐引用方式(GB/T 7714)：
Dong Zhiming,Guo Wei,Zhou Rongmiao,et al.Polymorphisms of the DNA repair gene XPA and XPC and its correlation with gastric cardiac adenocarcinoma in a high incidence population in North China.[J].Journal of clinical gastroenterology.2008,42(8):910-5.doi:10.1097/MCG.0b013e3180f6262c.
APA：
Dong Zhiming,Guo Wei,Zhou Rongmiao,Wan Lingling,Li Yan...&Wang Shijie.(2008).Polymorphisms of the DNA repair gene XPA and XPC and its correlation with gastric cardiac adenocarcinoma in a high incidence population in North China..Journal of clinical gastroenterology,42,(8)
MLA：
Dong Zhiming,et al."Polymorphisms of the DNA repair gene XPA and XPC and its correlation with gastric cardiac adenocarcinoma in a high incidence population in North China.".Journal of clinical gastroenterology 42..8(2008):910-5
