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XRCC5/6 polymorphisms and their interactions with smoking, alcohol consumption, and sleep satisfaction in breast cancer risk: A Chinese multi-center study(Open Access)

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机构： [1]Department of Breast Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China [2]Institute of Translational Medicine of Breast Disease Prevention and Treatment, Shandong University, Jinan, China [3]Department of Breast Surgery, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, China [4]Department of Breast Surgery, Shanxi Cancer Hospital, Taiyuan, China [5]Department of Breast Surgery, The First Hospital of Jilin University, Changchun, China [6]Department of Breast Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China [7]Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China [8]Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Binzhou Medical University, Binzhou, China [9]Department of Breast Surgery, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, China [10]Department of General Surgery, Linyi People's Hospital, Linyi, China [11]Department of Breast Disease Center, Peking University People's Hospital, Beijing, China [12]Department of General Surgery, Beijing Chaoyang Hospital, Beijing, China [13]Department of Breast Disease Center, Peking University First Hospital, Beijing, China [14]Department of Breast Center, Qingdao University Affiliated Hospital, Qingdao, China [15]Department of Breast and Thyroid Surgery, Weifang Traditional Chinese Hospital, Weifang, China [16]Department of Breast Surgery, Qingdao Central Hospital, Qingdao, China [17]Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China [18]Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China [19]Department of General Surgery, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, China [20]Department of Breast and Thyroid Surgery, Zibo Central Hospital, Zibo, China [21]Department of Breast Surgery, Yantai Yuhuangding Hospital, Yantai, China [22]Department of Breast Cancer Center, Shandong Cancer Hospital, Jinan, China

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关键词： alcohol consumption breast cancer gene-environment interaction sleep satisfaction smoking XRCC5 XRCC6

摘要：

Background: X-ray repair cross-complementary 5 (XRCC5) and 6 (XRCC6) are critical for DNA repair. Few studies have assessed their association with breast cancer risk, and related gene-environment interactions remain poorly understood. This study aimed to determine the influence of XRCC5/6 polymorphisms on breast cancer risk, and their interactions with cigarette smoking, alcohol consumption, and sleep satisfaction. Methods: The study included 1039 patients with breast cancer and 1040 controls. Four single-nucleotide polymorphisms of XRCC5 and two of XRCC6 were genotyped. Information about smoking, alcohol consumption, and sleep satisfaction was collected through questionnaires. Odds ratios (OR) and related 95% confidence intervals (95% CI) were assessed using unconditional logistic regression models. Gene-environment interactions were analyzed using logistic regression with multiplicative interaction models. Results: XRCC5 rs16855458 was associated with increased breast cancer risk in the co-dominant (ptrend = 0.003) and dominant (CA + AA vs. CC, OR = 1.29, 95% CI = 1.07–1.56, p = 0.008) genetic models after Bonferroni correction. The CG + GG genotype of XRCC6 rs2267437 was associated with an increased risk of estrogen receptor-negative/progesterone receptor-negative (ER−/PR−) breast cancer (CG + GG vs. CC: OR = 1.54, 95% CI = 1.12–2.13, p = 0.008) after Bonferroni correction. Moreover, an antagonistic interaction between XRCC5 rs16855458 and alcohol consumption (pinteraction = 0.017), and a synergistic interaction between XRCC6 rs2267437 and sleep satisfaction were associated with breast cancer risk (pinteraction = 0.0497). However, these interactions became insignificant after Bonferroni correction. Conclusion: XRCC5 rs16855458 was associated with breast cancer risk, and XRCC6 rs2267437 was associated with the risk of ER−/PR− breast cancer. Breast cancer risk associated with XRCC5 and XRCC6 polymorphisms might vary according to alcohol consumption and sleep satisfaction, respectively, and merit further investigation. © 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

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出版当年[2021]版：

大类 | 3 区医学

小类 | 3 区肿瘤学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区肿瘤学

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出版当年[2021]版：

Q2 ONCOLOGY

最新[2024]版：

Q2 ONCOLOGY

影响因子： 3.1 最新[2024版] 3.5 最新五年平均 4.711 出版当年[2021版] 4.842 出版当年五年平均 4.452 出版前一年[2020版] 4 出版后一年[2022版]

第一作者：

第一作者机构： [1]Department of Breast Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China [2]Institute of Translational Medicine of Breast Disease Prevention and Treatment, Shandong University, Jinan, China

通讯作者：

通讯机构： [1]Department of Breast Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China [2]Institute of Translational Medicine of Breast Disease Prevention and Treatment, Shandong University, Jinan, China [*1]247#, Beiyuan St, Tianqiao District, Jinan, Shandong 250033, China.

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XRCC5/6 polymorphisms and their interactions with smoking, alcohol consumption, and sleep satisfaction in breast cancer risk: A Chinese multi-center study(Open Access)

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