机构：[1]Department of Oncology, the First Hospital of Shanxi Medical University,Taiyuan, Shanxi Province 030012, China[2]Department of Internal Oncology,The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province050010, China河北医科大学第四医院肿瘤内科临床科室[3]Department of Oncology, Yantai Yuhuangding Hospital, Yantai,Shandong 264000, China[4]The Fourth Department of Oncology, Hebei GeneralHospital, Shijiazhuang, Hebei Province 050051, China
Increasing evidence demonstrates that long noncoding RNAs (lncRNAs) play critical roles in human breast cancer (BC) tumorigenesis. However, the mechanisms by which lncRNA and N6-methyladenosine (m6A) regulate BC tumorigenesis are still unclear. In the present research, LINC00958 was markedly overexpressed in BC tissue and cells, and LINC00958 upregulation promoted the tumor progression of BC cells. Mechanistically, m6A methyltransferase-like 3 (METTL3) gave rise to the upregulation of LINC00958 by promoting its RNA transcript stability. Moreover, LINC00958 acted as a competitive endogenous RNA for miR-378a-3p to promote YY1. Overall, these data provide novel insight into how m6A-mediated LINC00958 regulates BC tumorigenesis.
基金：
Science and Technology Project of Yantai City
(no. 2018SFGY114) and the Hebei Province Innovation Capacity Improvement
Project (no. 19392411D).
第一作者机构：[1]Department of Oncology, the First Hospital of Shanxi Medical University,Taiyuan, Shanxi Province 030012, China
通讯作者：
推荐引用方式(GB/T 7714)：
Rong Dongwen,Dong Qian,Qu Huajun,et al.m6A-induced LINC00958 promotes breast cancer tumorigenesis via the miR-378a-3p/YY1 axis.[J].CELL DEATH DISCOVERY.2021,7(1):doi:10.1038/s41420-020-00382-z.
APA：
Rong Dongwen,Dong Qian,Qu Huajun,Deng Xinna,Gao Fei...&Sun Ping.(2021).m6A-induced LINC00958 promotes breast cancer tumorigenesis via the miR-378a-3p/YY1 axis..CELL DEATH DISCOVERY,7,(1)
MLA：
Rong Dongwen,et al."m6A-induced LINC00958 promotes breast cancer tumorigenesis via the miR-378a-3p/YY1 axis.".CELL DEATH DISCOVERY 7..1(2021)
生物学