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Exogenous SO2 donor treatment impairs reconsolidation of drug reward memory in mice.

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机构： [1]Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, 410081, China [2]Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University, Shijiazhuang, 050017, China [3]National Institute on Drug Abuse, Molecular Targets and Medications Discovery Branch, Baltimore, MD, USA [4]Department of Functional Region of Diagnosis, Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, China [5]Collaborative Innovation Center of Forensic Medical Molecular Identification, Hebei Medicinal University, 050017, China

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关键词： Drug reward memory Sulfur dioxide Reconsolidation Relapse Morphine Cocaine Conditioned place preference SRAD

摘要：

Substance-related and addictive disorders (SRADs) are characterized by compulsive drug use and recurrent relapse. The persistence of pathological drug-related memories indisputably contributes to a high propensity to relapse. Hence, strategies to disrupt reconsolidation of drug reward memory are currently being pursued as potential anti-relapse interventions. Sulfur dioxide (SO2), acting as a potential gaseous molecule, endogenously derives from sulfur amino acid and can exert significant neural regulatory effects. However, the role of SO2 in reconsolidation of drug memory has not been determined. In the present study, we used morphine- or cocaine-induced conditioned place preference (CPP) mouse models with retrieval to investigate the effects of exogenous SO2 donor treatment on reconsolidation of drug reward memory. We found that administration of SO2 donor immediately after the retrieval impaired the expression of morphine or cocaine CPP. Furthermore, the exogenous SO2 donor treatment 6 h post-retrieval or in the absence of retrieval had no effect on drug reward memory and the expression of CPP. SO2 itself did not produce aversive effects nor did it acutely block morphine CPP. Our results indicate that exogenous SO2 impairs reconsolidation of drug reward memory rather than inhibits the expression of drug reward memory. As such, SO2 holds potential for the treatment and prevention of SRADs and should be studied further. Copyright © 2021 Elsevier B.V. All rights reserved.

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出版当年[2021]版：

大类 | 3 区医学

小类 | 3 区药学

最新[2025]版：

大类 | 3 区医学

小类 | 2 区药学

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出版当年[2021]版：

Q2 PHARMACOLOGY & PHARMACY

最新[2024]版：

Q1 PHARMACOLOGY & PHARMACY

影响因子： 4.7 最新[2024版] 4.7 最新五年平均 5.195 出版当年[2021版] 4.721 出版当年五年平均 4.432 出版前一年[2020版] 5 出版后一年[2022版]

第一作者：

第一作者机构： [1]Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, 410081, China [2]Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University, Shijiazhuang, 050017, China

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通讯作者：

通讯机构： [1]Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, 410081, China [2]Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University, Shijiazhuang, 050017, China [5]Collaborative Innovation Center of Forensic Medical Molecular Identification, Hebei Medicinal University, 050017, China [*1]Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, 410081, China. [*2]Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University, Shijiazhuang, 050017, China.

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Exogenous SO2 donor treatment impairs reconsolidation of drug reward memory in mice.

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