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LINC00239 interacts with c-Myc promoter-binding protein-1 (MBP-1) to promote expression of c-Myc in esophageal squamous cell carcinoma.

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收录情况： ◇ SCIE

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机构： [1]Laboratory of Pathology, Hebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

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Increasing evidence demonstrates that long non-coding RNAs (lncRNAs) play a vital role in the progression of tumors, containing esophageal squamous cell carcinoma (ESCC). LINC00239 was reported as an oncogene in diverse kinds of cancers, whereas its specific role is still unclear in ESCC. In this study, we detected the expression and functional role of LINC00239 in ESCC specimens and cells, and investigated the molecular mechanisms of it. LINC00239 was highly expressed in ESCC tissues and cells, and was related to poor prognosis of ESCC patients. The proliferation, metastasis, and invasion ability as well as epithelial-mesenchymal transition (EMT) process were all enhanced in LINC00239 overexpressed ESCC cells. LINC00239 was up-regulated in TGF-β1 treated ESCC cells. Furthermore, LINC00239 was found to bind directly to the transcription factor c-Myc promoter-binding protein-1 (MBP-1). MBP-1 was detected to inhibit the transcription of c-Myc in ESCC. Moreover, LINC00239 could activate c-Myc transcription through influencing MBP-1 binding ability to c-Myc promoter. These data suggest that LINC00239 may act as an oncogene to promote the transcription of c-Myc by competitively combining with MBP-1 in ESCC, and may serve as a potential target for antitumor therapy in ESCC. Implications: LINC00239 may function as an oncogenic lncRNA in ESCC through LINC00239/MBP-1/c-Myc axis to activate EMT process. Copyright ©2021, American Association for Cancer Research.

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出版当年[2021]版：

大类 | 2 区医学

小类 | 3 区细胞生物学 3 区肿瘤学

最新[2025]版：

大类 | 2 区医学

小类 | 3 区细胞生物学 3 区肿瘤学

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出版当年[2021]版：

Q2 CELL BIOLOGY Q2 ONCOLOGY

最新[2023]版：

Q2 CELL BIOLOGY Q2 ONCOLOGY

影响因子： 4.1 最新[2023版] 4.8 最新五年平均 6.333 出版当年[2021版] 6.75 出版当年五年平均 5.852 出版前一年[2020版] 5.2 出版后一年[2022版]

第一作者：

第一作者机构： [1]Laboratory of Pathology, Hebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

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通讯机构： [1]Laboratory of Pathology, Hebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. [*1]Laboratory of Pathology, Hebei Cancer Institute, the Fourth Hospital of Hebei Medical University, Jiankang Road 12, Shijiazhuang 050011, Hebei, China.

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