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Effects of the lncRNA ENST00000623984 on colon cancer and the biological characteristics of colon cancer cells.

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收录情况： ◇ SCIE

作者：

机构： [1]Oncology Department, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei [2]Oncology Department, Cangzhou Central Hospital, Cangzhou, Hebei, China

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关键词： LncRNA ENST00000623984 colorectal cancer expression PCR

摘要：

The aim of this study was to explore the effects of the lncRNA ENST00000623984 on colorectal cancer. In this study, the expression levels of ENST000000623984 were first examined in tumor tissue and adjacent normal tissue from 40 patients with colorectal cancer and LoVo cells using quantitative real-time PCR. By siRNA transfection, ENST00000623984 expression was knocked down. Using flow cytometry, cell cycle progression and cell viability were examined in basal and knockdown LoVo cells. The CCK-8 assay was used to assess the cell proliferation rate, and the Transwell assay was used to determine the migration and invasion abilities. The ENST000000623984 expression level was increased in colorectal cancer. Knockdown of ENST000000623984 reduced cell viability, proliferation rate, cell migration and invasion. These results suggested that lncRNA ENST000000623984 may be involved in colorectal cancer development.

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中科院分区：

出版当年[2021]版：

大类 | 3 区生物

小类 | 4 区细胞生物学

最新[2025]版：

大类 | 4 区生物学

小类 | 4 区细胞生物学

JCR分区：

出版当年[2021]版：

Q4 CELL BIOLOGY

最新[2023]版：

Q4 CELL BIOLOGY

影响因子： 2.1 最新[2023版] 2 最新五年平均 1.966 出版当年[2021版] 2.37 出版当年五年平均 3.188 出版前一年[2020版] 2 出版后一年[2022版]

第一作者：

第一作者机构： [1]Oncology Department, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei [2]Oncology Department, Cangzhou Central Hospital, Cangzhou, Hebei, China

通讯作者：

通讯机构： [1]Oncology Department, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei [*1]Department, The Fourth Hospital of Hebei Medical University, No. 12 Health Road, Shijiazhuang, 050011, Hebei, China.

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