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Inspiration for the prevention and treatment of neuropsychiatric disorders: New insight from the bone-brain-axis.

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机构： [1]Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University, Shijiazhuang 050017, China [2]Hebei Key laboratory of Neurophysiology, Hebei Medicinal University, 050017, China [3]Child Health Department, Hebei Children’s Hospital, Shijiazhuang 050031, China [4]Department of Biochemistry and Molecular Biology, College of Basic Medicine, Hebei Medicinal University, Shijiazhuang 050017, China [5]Department of Functional Region of Diagnosis, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China

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关键词： Bone Central nervous system Bone-brain-axis Endocrine Exercise

摘要：

Bone is the main supporting structure of the body and the main organ involved in body movement and calcium and phosphorus metabolism. Recent studies have shown that bone is also a potential new endocrine organ that participates in the physiological and pathophysiological processes of the cardiovascular, digestive, and endocrine systems through various bioactive cytokines secreted by bone cells and bone marrow. Bone-derived active cytokines can also directly act on the central nervous system and regulate brain function and individual behavior. The bidirectional regulation of the bone-brain axis has gradually attracted attention in the field of neuroscience. This paper reviews the regulatory effects of bone-derived active cytokines and bone-derived cells on individual brain function and brain diseases, as well as the occurrence and development of related neuropsychiatric diseases. The central regulatory mechanism function is briefly introduced, which will broaden the scope for mechanistic research and help establish prevention and treatment strategies for neuropsychiatric diseases based on the bone-brain axis.Copyright © 2021 Elsevier Inc. All rights reserved.

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出版当年[2021]版：

大类 | 3 区医学

小类 | 3 区神经科学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区神经科学

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Q3 NEUROSCIENCES

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Q2 NEUROSCIENCES

影响因子： 3.7 最新[2024版] 3.6 最新五年平均 3.715 出版当年[2021版] 4.113 出版当年五年平均 4.079 出版前一年[2020版] 3.8 出版后一年[2022版]

第一作者：

第一作者机构： [1]Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University, Shijiazhuang 050017, China [2]Hebei Key laboratory of Neurophysiology, Hebei Medicinal University, 050017, China

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通讯作者：

通讯机构： [1]Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University, Shijiazhuang 050017, China [2]Hebei Key laboratory of Neurophysiology, Hebei Medicinal University, 050017, China [4]Department of Biochemistry and Molecular Biology, College of Basic Medicine, Hebei Medicinal University, Shijiazhuang 050017, China [5]Department of Functional Region of Diagnosis, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China [*1]Neuroscience Research Center, Institute of Medical and Health Science of HeBMU, Hebei Medical University, Shijiazhuang 050017, China.

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Inspiration for the prevention and treatment of neuropsychiatric disorders: New insight from the bone-brain-axis.

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