LncRNA DDX11 antisense RNA 1 promotes EMT process of esophageal squamous cell carcinoma by sponging miR-30d-5p to regulate SNAI1/ZEB2 expression and Wnt/beta-catenin pathway
机构：[1]Hebei Med Univ, Hebei Canc Inst, Hosp 4, Shijiazhuang, Hebei, Peoples R China河北医科大学第四医院[2]Capital Med Univ, Beijing Shijitan Hosp, Beijing, Peoples R China
LncRNA DDX11 antisense RNA 1 (DDX11-AS1) is recognized as having an imperative oncogenic role in different types of human cancer. Nevertheless, the functions, as well as the basic mechanisms of DDX11-AS1 in the EMT process of esophageal squamous cell carcinoma (ESCC), are yet to be clarified. In this research, high DDX11-AS1 expression was detected in ESCC cells as well as tissues and was linked to the poor prognosis of patients with ESCC. DDX11-AS1 promoted cell proliferation, migration, invasion ability and epithelial mesenchymal transition (EMT) process in vitro. Mechanistic analysis depicted that DDX11-AS1 may function as a ceRNA through sponging miR-30d-5p to upregulate the expression of SNAI1 and ZEB2. Meanwhile, overexpression of DDX11-AS1 might cause the activation of the Wnt/beta-catenin signaling pathway via targeting miR-30d-5p. On the whole, the findings of this research illustrate that DDX11-AS1 may act as an EMT-related lncRNA to advance ESCC progression through sponging miR-30d-5p to regulate SNAI1/ZEB2 expression and activate the Wnt/beta-catenin pathway, which indicates that it might serve as a probable therapeutic target for ESCC.
基金：
Natural Science Foundation of Hebei Province of China (No. H2019206664, to Z.M.D);
The Natural Science Foundation of Hebei Province of China
(No. H2020206368 to Y.L.G); The focal point Project of
Hebei medical research (No. 20170698, to Y.L.G); Talent
Engineering Training Project of Hebei Province
(No.201901035, to Y.L.G).
第一作者机构：[1]Hebei Med Univ, Hebei Canc Inst, Hosp 4, Shijiazhuang, Hebei, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Hebei Med Univ, Hebei Canc Inst, Hosp 4, Shijiazhuang, Hebei, Peoples R China[*1]Hebei Cancer Institute,The Fourth Hospital of Hebei Medical University, Shijiazhuang, China
推荐引用方式(GB/T 7714)：
Guo Yanli,Sun Pingping,Guo Wei,et al.LncRNA DDX11 antisense RNA 1 promotes EMT process of esophageal squamous cell carcinoma by sponging miR-30d-5p to regulate SNAI1/ZEB2 expression and Wnt/beta-catenin pathway[J].BIOENGINEERED.2021,12(2):11425-11440.doi:10.1080/21655979.2021.2008759.
APA：
Guo, Yanli,Sun, Pingping,Guo, Wei,Yin, Qing,Han, Junshu...&Dong, Zhiming.(2021).LncRNA DDX11 antisense RNA 1 promotes EMT process of esophageal squamous cell carcinoma by sponging miR-30d-5p to regulate SNAI1/ZEB2 expression and Wnt/beta-catenin pathway.BIOENGINEERED,12,(2)
MLA：
Guo, Yanli,et al."LncRNA DDX11 antisense RNA 1 promotes EMT process of esophageal squamous cell carcinoma by sponging miR-30d-5p to regulate SNAI1/ZEB2 expression and Wnt/beta-catenin pathway".BIOENGINEERED 12..2(2021):11425-11440
