机构：[1]School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China.[2]Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, Hebei, China.[3]Cardiac Surgery Department, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.临床科室心外科河北医科大学第四医院
Acute aortic dissection (AAD) is very fatal without surgical treatment. Higher serum sodium can increase in-hospital mortality of many diseases; however, the effect of serum sodium on postoperative in-hospital mortality in AAD patients remains unknown.We collected a total of 415 AAD patients from January 2015 to December 2019. Patients were classified into four categories (Q1-Q4) according to the admission serum sodium quartile. The cox proportional hazards model evaluated the association between serum sodium and in-hospital mortality. All-cause in-hospital mortality was set as the endpoint.By adjusting many covariates, cox proportional hazards model revealed the in-hospital mortality risk of both Q3 and Q4 groups was 3.086 (1.242-7.671, P = 0.015) and 3.370 (1.384-8.204, P = 0.007) respectively, whereas the risk of Q2 group was not significantly increased. Univariate and multiple Cox analysis revealed that Stanford type A, serum glucose, α-hydroxybutyrate dehydrogenase and serum sodium were risk factors correlated with in-hospital death in AAD patients.The study indicates that the admission serum sodium of AAD patients has a vital impact on postoperative hospital mortality.
基金：
Our gratitude goes to the National Natural
Science Foundation of China (No.81700416)
第一作者机构：[1]School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China.
共同第一作者：
通讯作者：
通讯机构：[1]School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China.[2]Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, Hebei, China.
推荐引用方式(GB/T 7714)：
Huang Pengfei,Wang Hongyan,Ma Dong,et al.Serum sodium on admission affects postoperative in-hospital mortality in acute aortic dissection patients.[J].PLOS ONE.2021,16(12):doi:10.1371/journal.pone.0261168.
APA：
Huang Pengfei,Wang Hongyan,Ma Dong,Zhao Yongbo,Liu Xiao...&Zhang Ling.(2021).Serum sodium on admission affects postoperative in-hospital mortality in acute aortic dissection patients..PLOS ONE,16,(12)
MLA：
Huang Pengfei,et al."Serum sodium on admission affects postoperative in-hospital mortality in acute aortic dissection patients.".PLOS ONE 16..12(2021)
