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Clinical Significance and Risk Factors of Local Recurrence in Synovial Sarcoma: A Retrospective Analysis of 171 Cases.

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机构： [1]Department of Surgical Oncology, Shanghai Cancer Center Minhang Branch Hospital, Fudan University, Shanghai, China. [2]Department of Musculoskeletal Oncology, Shanghai Cancer Center, Fudan University, Shanghai, China. [3]Department of Oncology, Shanghai Medical College of Fudan University, Shanghai, China. [4]Department of Orthopedics, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China. [5]Department of Surgery Base, Shanghai Cancer Center, Fudan University, Shanghai, China. [6]Department of Surgery, Brandon Regional Hospital, Morsani College of Medicine, Hospital Corporation of America Healthcare/University of South Florida Health, Tampa, FL, United States. [7]Department of Pathology, Shanghai Cancer Center, Fudan University, Shanghai, China.

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关键词： synovial sarcoma local recurrence overall survival (OS) prognosis risk factor

摘要：

Objective: To investigate risk factors of local recurrence of synovial sarcoma and the impact of local recurrence on survival. Methods: We retrospectively reviewed clinical data of patients with II to IIIB (AJCC8) synovial sarcoma who underwent surgery at our center between March 2005 and December 2016. Data relating clinicopathological factors, treatment and prognosis were collected. The impact of local recurrence on overall survival (OS), local recurrence-free survival (LRFS), and distant relapse-free survival (DRFS) were analyzed. The prognostic factors associated with local recurrence were also analyzed using Kaplan-Meier Curves and Cox regression analysis. Results: A total of 171 patients were included in this analysis. After a median follow-up of 48 months, 66 patients (38.6%) experienced local recurrence. The 5-year OS, LRFS, and DRFS rates of patients with local recurrence were 37.6, 6.1, and 24.1%, respectively. Multivariate analysis showed that larger initial tumors, multiple recurrences, positive resection margins, marginal resection, and lack of adjuvant therapy were associated with higher local recurrence. Conclusion: Local recurrence of synovial sarcoma is associated with distant metastasis and poor survival. Chemoradiation improves the prognosis of patients with local recurrence, in particular those for which recurrence occurs shortly after initial treatment.Copyright © 2022 Zhang, Huang, Feng, Sun, Yan, Wang, Zhang, Huang, Yu, Qu and Chen.

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出版当年[2022]版：

大类 | 4 区医学

小类 | 4 区外科

最新[2025]版：

大类 | 4 区医学

小类 | 4 区外科

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出版当年[2022]版：

Q3 SURGERY

最新[2023]版：

Q2 SURGERY

影响因子： 1.6 最新[2023版] 1.7 最新五年平均 1.8 出版当年[2022版] 2 出版当年五年平均 2.568 出版前一年[2021版] 1.6 出版后一年[2023版]

第一作者：

第一作者机构： [1]Department of Surgical Oncology, Shanghai Cancer Center Minhang Branch Hospital, Fudan University, Shanghai, China.

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通讯作者：

通讯机构： [2]Department of Musculoskeletal Oncology, Shanghai Cancer Center, Fudan University, Shanghai, China. [3]Department of Oncology, Shanghai Medical College of Fudan University, Shanghai, China.

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Clinical Significance and Risk Factors of Local Recurrence in Synovial Sarcoma: A Retrospective Analysis of 171 Cases.

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