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Chinese Medicine Formula Siwu-Yin Inhibits Esophageal Precancerous Lesions by Improving Intestinal Flora and Macrophage Polarization.

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收录情况： ◇ SCIE

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机构： [1]Department of Traditional Chinese Medicine, The Fourth Hospital of Hebei Medical University, Hebei Cancer Hospital, Shijiazhuang, China. [2]Institute for Biotechnology, St. John's University, Queens, NY, United States. [3]Pharmacy Department, The Fourth Hospital of Hebei Medical University, Hebei Cancer Hospital, Shijiazhuang, China. [4]College of Integrated Traditional Chinese and Western Medicine, Hebei Medical University, Shijiazhuang, China. [5]Hebei Ping An Health Group Pharmaceutical Research Institute, Shijiazhuang, China. [6]Health Food Research Office, Shijiazhuang Yiling Pharmaceutical Co., Ltd., Shijiazhuang, China.

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Siwu-Yin (SWY), a traditional Chinese medicinal formula, can replenish blood and nourish Yin. It was recorded in ancient Chinese medicine books in treating esophageal dysphagia, which has similar symptoms and prognosis with esophageal precancerous lesions and esophageal cancer. However, its effect has not been established in vivo. This study explores the antiesophageal cancer effect of SWY on rats with esophageal precancerous lesions. By performing 16S rRNA gene sequencing and metabolomics, it was suggested that SWY may improve the composition of intestinal flora of rats by regulating the synthesis and secretion of bile acids. In addition, flow cytometry results showed that SWY treatment modified tumor microenvironment by improving macrophage polarization and therefore inhibiting the occurrence of esophageal precancerous lesions.Copyright © 2022 Shi, Chen, Chen, Wu, Li, Sun, Shi and Li.

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中科院分区：

出版当年[2022]版：

大类 | 2 区

医学

小类 | 2 区药学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区药学

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出版当年[2022]版：

Q1 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q1 PHARMACOLOGY & PHARMACY

影响因子： 4.4 最新[2023版] 5 最新五年平均 5.6 出版当年[2022版] 6.1 出版当年五年平均 5.988 出版前一年[2021版] 4.4 出版后一年[2023版]

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第一作者机构： [1]Department of Traditional Chinese Medicine, The Fourth Hospital of Hebei Medical University, Hebei Cancer Hospital, Shijiazhuang, China.

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通讯作者：

通讯机构： [1]Department of Traditional Chinese Medicine, The Fourth Hospital of Hebei Medical University, Hebei Cancer Hospital, Shijiazhuang, China. [4]College of Integrated Traditional Chinese and Western Medicine, Hebei Medical University, Shijiazhuang, China.

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