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Identification of Prostate Cancer Risk Genetics Biomarkers Based on Intergraded Bioinformatics Analysis.

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收录情况： ◇ SCIE

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机构： [1]Department of Urology, The Fourth Hospital of Hebei Medical University, Shijiahzuang, China

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关键词： prostate cancer (PCa) bioinformatics analysis immune cell infiltration survival analysis ARHGEF38 KCNK3 AK5

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Prostate cancer (PCa) is one of the most popular cancer types in men. Nevertheless, the pathogenic mechanisms of PCa are poorly understood. Hence, we aimed to identify the potential genetic biomarker of PCa in the present study.High-throughput data set GSE46602 was obtained from the comprehensive gene expression database (GEO) for screening differentially expressed genes (DEGs). The common DEGs were further screened out using The Cancer Genome Atlas (TCGA) dataset. Functional enrichment analysis includes Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) to study related mechanisms. The Cox and Lasso regression analyses were carried out to compress the target genes and construct the high-risk and low-risk gene model. Survival analyses were performed based on the gene risk signature model. The CIBERSORT algorithm was performed to clarify the correlation of the high- and low-risk gene model in risk and infiltration of immune cells in PCa.A total of 385 common DEGs were obtained. The results of functional enrichment analysis show that common DEGs play an important role in PCa. A three-gene signature model (KCNK3, AK5, and ARHGEF38) was established, and the model was significantly associated with cancer-related pathways, overall survival (OS), and tumor microenvironment (TME)-related immune cells in PCa.This new risk model may contribute to further investigation in the immune-related pathogenesis in progression of PCa.Copyright © 2022 Liang, Wang, Pei, Tan and Dong.

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出版当年[2022]版：

大类 | 4 区医学

小类 | 4 区外科

最新[2025]版：

大类 | 4 区医学

小类 | 4 区外科

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出版当年[2022]版：

Q3 SURGERY

最新[2023]版：

Q2 SURGERY

影响因子： 1.6 最新[2023版] 1.7 最新五年平均 1.8 出版当年[2022版] 2 出版当年五年平均 2.568 出版前一年[2021版] 1.6 出版后一年[2023版]

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第一作者机构： [1]Department of Urology, The Fourth Hospital of Hebei Medical University, Shijiahzuang, China

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通讯机构： [1]Department of Urology, The Fourth Hospital of Hebei Medical University, Shijiahzuang, China

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