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The association between anion gap and in-hospital mortality of post-cardiac arrest patients: a retrospective study.

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机构： [1]The Third Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou 310000, Zhejiang, China. [2]The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310000, Zhejiang, China. [3]Department of Intensive Care Unit, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

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We aimed to determine the association between anion gap and in-hospital mortality in post-cardiac arrest (CA) patients. Extracted the data of patients diagnosed with CA from MIMIC-IV database. Generalized additive model (GAM), Cox regression and Kaplan-Meier survival analysis were used to demonstrate the association between AG levels and in-hospital mortality. ROC curve analysis for assessing the discrimination of AG for predicting in-hospital mortality. Totally, 1724 eligible subjects were included in our study finally. 936 patients (551 males and 385 females) died in hospital, with the prevalence of in-hospital mortality was 54.3%. The result of the Kaplan-Meier analysis showed that the higher value of AG had significant lower survival possibility during the hospitalization compared with the lower-value of AG patients. In the crude Cox regression model, high-level of AG subjects was associated with significant higher HR compared with low-level of AG subjects. After adjusted the vital signs data, laboratory data, and treatment, high-level of AG (group Q3 and group Q4) were also associated with increased risk of in-hospital mortality compared with low-level of AG group, 1.52 (95% Cl 1.17-1.85; P < 0.001), 1.64 (95% Cl 1.21-2.08; P < 0.001), respectively. The ROC curve indicated that AG has acceptable discrimination for predicting in-hospital mortality. The AUC value was found to be 0.671 (95% CI 0.646-0.698). Higher AG levels was associated with poor prognosis in post-CA patients. AG is a predictor for predicting in-hospital mortality of CA, and could help refine risk stratification.© 2022. The Author(s).

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出版当年[2022]版：

大类 | 3 区综合性期刊

小类 | 3 区综合性期刊

最新[2025]版：

大类 | 3 区综合性期刊

小类 | 3 区综合性期刊

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出版当年[2022]版：

Q2 MULTIDISCIPLINARY SCIENCES

最新[2024]版：

Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 3.9 最新[2024版] 4.3 最新五年平均 4.6 出版当年[2022版] 4.9 出版当年五年平均 4.997 出版前一年[2021版] 3.8 出版后一年[2023版]

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第一作者机构： [2]The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310000, Zhejiang, China.

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通讯机构： [1]The Third Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou 310000, Zhejiang, China. [2]The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310000, Zhejiang, China.

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