研究单位：[1]Peking University First Hospital[2]Peking University First Hospital,Beijing,Beijing, China,China,100034[3]Tsinghua University Yuquan Hospital,Beijing,Beijing,China,100040[4]Cancer Hospital Chinese Academy of Medical Sciences,Beijing,Beijing,China,200032[5]The First Affiliated Hospital of Army Medical University (Southwest Hospital),Chongqing,Chongqing,China,400038[6]Fujian Provincial Hospital,Fuzhou,Fujian,China,350001[7]The First Affiliated Hospital of Fujian Medical University,Fuzhou,Fujian,China,350004[8]Fujian Medical University Union Hospital,Fuzhou,Fujian,China,Fujian[9]Guangdong General Hospital,Guangzhou,Guangdong,China,Guangdong[10]Peking University Shenzhen Hospital,Shenzhen,Guangdong,China,518034[11]The First Affiliated Hospital of Shenzhen University,Shenzhen,Guangdong,China,518035[12]Affiliated Cancer Hospital of Guangxi Medical University,Nanning,Guangxi,China,530021[13]The Second Affiliated Hospital of Guangxi Medical University,Nanning,Guangxi,China,Guangxi[14]Zhejiang Cancer Hospital,Zhejiang,Hangzhou,China,310022[15]The First Affiliated Hospital of China University of Science and Technology,Hefei,Hebei,China,065001[16]The First Affiliated Hospital of China University of Science and Technology(Anhui Provincial Hospital),Hefei,Hebei,China,230001[17]The Fourth Hospital of Hebei Medical University,Shijiazhuang,Hebei,China,050011[18]Tangshan Workers'' Hospital,Tangshan,Hebei,China,063000[19]The Second Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang,China,150001[20]Harbin Medical University Cancer Hospital,Harbin,Heilongjiang,China,150081[21]The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan,China,450052[22]Henan Provincial People''s Hospital,Zhengzhou,Henan,China,463599[23]Xiangya Hospital Central south university,Changsha,Hunan,China,410119[24]The First Affiliated Hospital of University of South China,Hengyang,Hunan,China,421005[25]Affiliated Drum Tower Hospital, Medical School of Nanjing University,Nanjing,Jiangsu,China,210008[26]The Second Affiliated Hospital of Suzhou University,Suzhou,Jiangsu,China,215004[27]Bethune First Hospital Of Jilin University,Changchun,Jilin,China,130031[28]General hospital of eastern theater command,Nanjing,Nanjing,China,210002[29]General Hospital of Ningxia Medical University,Yinchuan,Ningxia,China,750003[30]People''s Hospital of Ningxia Hui Autonomous Region,Yinchuan,Ningxia,China,750011[31]Xijing Hospital, Fourth Military Medical University,Xi''an,Shaanxi,China,710032[32]Shandong Provincial Hospital Heze Hospital,Heze,Shandong,China,274000[33]Shanghai Fourth People''s Hospital Affiliated to Tongji University School of Medicine,Shanghai,Shanghai,China,200123[34]First Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang,China,830011[35]The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang,China,325000
Along with aging population, cancer incidence and mortality are increasing. However, despite advances in oncology and surgery, long-term survival of cancer patients is far from optimal. Dexmedetomidine is a highly selective alpha 2 adrenergic receptor agonist with sedative, analgesic, and anxiolytic effects. Studies showed that perioperative use of dexmedetomidine reduces delirium and some non-delirium complications after surgery. In long-term follow-up studies of older patients who, for other reasons, were randomized to receive either dexmedetomidine or placebo during intra- or postoperative period, dexmedetomidine use was associated with improved long-term survival. This multicenter randomized trial aims to investigate the effect of perioperative dexmedetomidine on long-term outcomes in older patients undergoing cancer surgery.
