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A Study of Mitoxantrone Hydrochloride Liposome Injection in Patients With Advanced HER2 Negative Breast Cancer

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研究单位： [1]CSPC ZhongQi Pharmaceutical Technology Co., Ltd. [2]Cancer Center Sun Yat-sen University Guozhou, Guodong, China, 510060 [3]Affiliated Hospital of Hebei University Baoding, Hebei, China, 071030 [4]The Fourth Hospital of Hebei Medical University Shijiazhuang, Hebei, China, 050000 [5]Tangshan People's Hospital Tangshan, Hebei, China, 063000 [6]Xingtai People's Hospital Xingtai, Hebei, China, 054000 [7]Harbin Medical University Cancer Hospital Harbin, Heilongjiang, China, 150008 [8]Daqing People's Hospital Daqing, Helongjiang, China, 163316 [9]Cancer Hospital of Jiamusi City Jiamusi, Helongjiang, China, 154007 [10]The First Affiliated Hospital of Xinxiang Medical University Xinxiang, Henan, China, 453100 [11]Cancer Hospital of Henan Province Zhengzhou, Henan, China, 450008 [12]The First Affiliated Hospital of Zhengzhou University Zhengzhou, Henan, China, 450052 [13]Henan Provincial People's Hospital Zhenzhou, Henan, China, 450008 [14]Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology Wuhan, Hubei, China, 430022 [15]Zhongnan Hospital of Wuhan University Wuhan, Hubei, China, 430071 [16]Hubei Cancer Hospital Wuhan, Hubei, China, 430079 [17]Changsha Kexin Cancer Hospital Changsha, Hunan, China, 413002 [18]Yiyang Central Hospital Yiyang, Hunan, China, 413002 [19]The third Hospital of Nanchang Nanchang, Jiangxi, China, 330000 [20]The second hospital of Jinlin University Changchun, Jinlin, China, 130041 [21]The second hospital of Dalian Medical University Dalian, Liaoning, China, 116023 [22]The First Affiliated Hospital of Jinzhou Medical University Jinzhou, Liaoning, China, 121000 [23]The First hospital of China Medical University Shenyang, Liaoning, China, 110000 [24]Shanxi Provincial Cancer Hospital Taiyuan, Shanxi, China, 0300001 [25]Yuncheng Central Hospital Yuncheng, Shanxi, China, 044000 [26]Sichuan Cancer Hospital & Institute Chengdu, Sichuan, China, 610041 [27]The second people's hospital of neijiang Neijiang, Sichuan, China, 641100 [28]Affiliated tumor Hospital of Xinjiang Medical University Urumqi, Xinjiang, China, 830011 [29]The First Affiliated Hospital of Xinjiang Medical University Urumqi, Xinjiang, China, 830011 [30]Anhui Provincial Hospical Hefei, Anhui, China, 230000

研究目的：

This is a multicenter, open-label, single-arm, phase II study to evaluate the safety and efficacy of Mitoxantrone Hydrochloride Liposome in patients with advanced HER2 negative breast cancer.