A Study of Tislelizumab (BGB-A317) Versus Chemotherapy as Second Line Treatment in Participants With Advanced Esophageal Squamous Cell Carcinoma
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研究单位：[1]BeiGene[2]University of Southern California Norris Comprehensive Cancer Center Los Angeles, California, United States, 90089-0112[3]Northwestern Medicine Cancer Center Warrenville Warrenville, Illinois, United States, 60555[4]Henry Ford Hospital Detroit, Michigan, United States, 48202[5]Toledo Clinic Cancer Center Toledo, Ohio, United States, 43623[6]San Antonio Military Medical Center Fort Sam Houston, Texas, United States, 78234[7]Millennium Oncology Houston, Texas, United States, 77090[8]Imelda Ziekenhuis Antwerp, Belgium, 2600[9]UZ Antwerpen Antwerp, Belgium, 2650[10]Cliniques universitaires Saint-Luc Brussels, Belgium, 1000[11]University Hospitals Leuven Leuven, Belgium, 3000[12]Centre Hospitalier Universitaire (CHU) de Liege - Site du Sart Tilman Liege, Belgium, 4000[13]Anhui Medical University - The Second Hospital Hefei, Anhui, China, 230601[14]Beijing Friendship Hospital Beijing, Beijing, China, 100050[15]Beijing Cancer Hospital Beijing, Beijing, China, 100142[16]Peking Union Medical College Hospital Beijing, Beijing, China, 100730[17]Fujian Medical University Union Hospital Fuzhou, Fujian, China, 350001[18]The First Affiliated Hospital of Fujian Medical University Fuzhou, Fujian, China, 350005[19]Fujian Provincial Cancer Hospital Fuzhou, Fujian, China, 350014[20]The First Affiliated Hospital of Xiamen University Xiamen, Fujian, China, 361004[21]The First Hospital, Sun Yat-sen University Guangzhou, Guangdong, China, 510080[22]The Sixth Affiliated Hospital of Sun Yat-sen University Guangzhou, Guangdong, China, 510655[23]Cancer Hospital of Shantou University Medical College Shantou, Guangdong, China, 515031[24]Peking University Shenzhen Hospital Shenzhen, Guangdong, China, 518035[25]Affiliated Hospital of Hebei University Baoding, Hebei, China, 71000[26]Fourth Hospital of Hebei Medical University Shijiazhuang, Hebei, China, 050011河北医科大学第四医院[27]Harbin Medical University Cancer Hospital Harbin, Heilongjiang, China, 150081[28]The First Affiliated Hospital of Xinxiang Medical University Xinxiang, Henan, China, 453100[29]Henan Cancer Hospital Zhengzhou, Henan, China, 450008[30]The First Affiliated Hospital of Zhengzhou University Zhengzhou, Henan, China, 450052[31]Hubei Cancer Hospital Wuhan, Hubei, China, 400037[32]Xiangyang Central Hospital Xiangyang, Hubei, China, 441000[33]Hunan Cancer Hospital Changsha, Hunan, China, 410013[34]The First People's Hospital Of Changzhou Changzhou, Jiangsu, China, 213003[35]Huai'an Second People's Hospital Huai'an, Jiangsu, China, 223002[36]Jiangsu Province Hospital Nanjing, Jiangsu, China, 210029[37]Nanjing Drum Tower Hospital Nanjing, Jiangsu, China, 21008[38]Nantong Tumor Hospital Nantong, Jiangsu, China, 226000[39]The Affiliated Hospital of Xuzhou Medical University Xuzhou, Jiangsu, China, 221002[40]Jiangxi Cancer Hospital Nanchang, Jiangxi, China, 330029[41]The First Hospital of Jinlin University Changchun, Jilin, China, 130021[42]Shandong Cancer Hospital Jinan, Shandong, China, 250117[43]Shandong Linyi Tumor Hospital Linyi, Shandong, China, 371300[44]WeiFang People's Hospital Weifang, Shandong, China, 261000[45]Fudan Cancer Hospital Shanghai, Shanghai, China, 200032[46]Shanxi Provincial People's Hospital Taiyuan, Shanxi, China, 140100[47]The Second Affiliated Hospital of Xi'an Jiaotong University(Xibei Hospital) Xi'an, Shanxi, China, 710014[48]Sichuan Academy of Medical Sciences& Sichuan Provincial People's Hospital Chengdu, Sichuan, China, 610071[49]Yunnan Cancer Hospital - Oncology Kunming, Yunnan, China, 650100[50]Hangzhou First People's Hospital Hangzhou, Zhejiang, China, 310006[51]The First Affiliated Hospital, Zhejiang University Hangzhou, Zhejiang, China, 310006[52]Zhejiang Cancer Hospital Hangzhou, Zhejiang, China, 310022[53]CHRU Besançon Besançon, France, 25000[54]CHRU de Brest Hôpital Morvan Brest, France, 29200[55]Centre Georges-Francois Leclerc Dijon, France, 21079[56]Center Oscar Lambret - Alliance Member Lille, France, 59000[57]Hopital Prive Jean Mermoz Lyon, France, 69008[58]ICM Val d'Aurelle Montpellier, France, 34298[59]Comprehensive Cancer Center-Gustave Roussy Paris, France, 94805[60]Hôpital Haut-Lévêque Pessac, France, 33604[61]CHU de Poitiers Poitiers, France, 86021[62]Centre de Lutte Contre le Cancer Saint-Herblain, France, 44805[63]Clinique Sainte-Anne Strasbourg, France, 67000[64]Charite - Universitatsmedizin Berlin /Campus Virchow Klinikum (CVK) - Med. Klinik m. S. Hamatologie, Onkologie und Tumorimmunologie (CC14) Berlin, Germany, 13353[65]Universitatsklinikum Carl Gustav Carus Dresden, Medizinische Klinik und Poliklinik Dresden, Germany, 01307[66]Hamatologisch-Onkologische Praxis Eppendorf (HOPE) Hamburg, Germany, 20249[67]Asklepios Klinik Altona Hamburg, Germany, 22763[68]Universitatsklinikum Koln, Innere Medizin I Koln, Germany, 50937[69]Universitat Leipzig, UKL AoR, Universitares Krebszentrum Leipzig (UCCL) Leipzig, Germany, 04103[70]Universitaetsmedizin der Johannes Gutenberg-Universitat Mainz Mainz, Germany, 55131[71]Universitaetsmedizin Mannheim, II. Medizinische Klinik Mannheim, Germany, 68167[72]Kliniken Nordoberpfalz, Klinikum Weiden Weiden, Germany, 92637[73]PO Garibaldi-Nesima, ARNAS Garibaldi Catania, Italy, 95122[74]AUSL della Romagna, Osp. degli Infermi Faenza, Italy, 48018[75]Irccs Irst Meldola, Italy, 47014[76]AOU - Seconda Università degli Studi di Napoli Naples, Italy, 80131[77]AOU San Luigi di Orbassano Orbassano, Italy, 10043[78]Ospedale Guglielmo da Saliceto, AUSL Piacenza Piacenza, Italy, 29121[79]A.O.U. Pisana, Stabilimento di Santa Chiara Pisa, Italy, 56126[80]AO Citta della Salute e della Scienza di Torino - Presidio O Torino, Italy, 10126[81]National Cancer Center Hospital East Kashiwa, Chiba, Japan, 100-0045[82]Shikoku Cancer Center Matsuyama, Ehime, Japan, 791-0280[83]Hyogo Cancer Center Akashi, Hyogo, Japan, 673-8558[84]Kobe City Medical Center General Hospital Kobe, Hyogo, Japan, 650-0047[85]St. Marianna University School of Medicine Hospital Kawasaki, Kanagawa, Japan, 216-8511[86]Kindai University Nara Hospital Ikoma, Nara, Japan, 630-0293[87]Osaka University Hospital Suita, Osaka, Japan, 565-0871[88]Saitama Cancer Center Ina, Saitama, Japan, 362-0806[89]Shizuoka Cancer Center Nagaizumi, Shizuoka, Japan, 411-8777[90]National Cancer Center Hospital Chuo-ku, Tokyo, Japan, 104-0045[91]The Cancer Institute Hospital of JFCR Koto-Ku, Tokyo, Japan, 135-8550[92]Akita University Hospital Akita, Japan, 010-8543[93]Chiba Cancer Center Chiba, Japan, 260-8717[94]National Kyushu Cancer Center Fukuoka, Japan, 811-1395[95]Hiroshima University Hospital Hiroshima, Japan, 734-8551[96]Kagawa University Hospital Kagawa, Japan, 761-0793[97]Kochi Health Sciences Center Kochi, Japan, 781-8555[98]Kyoto University Hospital Kyoto, Japan, 606-8507[99]Osaka International Cancer Institute Osaka, Japan, 541-8567[100]Osaka Medical College Hospital Osaka, Japan, 569-8686[101]Gachon University Gil Medical Center Incheon, Korea, Republic of, 21565[102]Seoul National University Bundang Hospital Seongnam-si, Korea, Republic of, 13620[103]Asan Medical Center - Oncology Seoul, Korea, Republic of, 5505[104]Chonnam National University Hwasun Hospital Seoul, Korea, Republic of, 58128[105]Samsung Medical Center Seoul, Korea, Republic of, 6351[106]Korea University Guro Hospital Seoul, Korea, Republic of, 8308[107]Hospital del Mar Barcelona, Madrid, Spain, 08003[108]Hospital Universitario Vall d'Hebron Barcelona, Spain, 08035[109]Hospital Clinic de Barcelona Barcelona, Spain, 08036[110]Institut Català d'Oncologia Madrid, Spain, 08908[111]Hospital Madrid Norte Sanchinarro Madrid, Spain, 28006[112]Hospital Universitario Gregorio Marañon Madrid, Spain, 28009[113]Hospital Universitario Ramón y Cajal Madrid, Spain, 28034[114]Hospital Universitario 12 de Octubre Madrid, Spain, 28041[115]Hospital Universitario Virgen de la Arrixaca Murcia, Spain, 30120[116]Hospital Universitario Miguel Servet Zaragoza, Spain, 50009[117]Changhua Christian Hospital Changhua, NAP, Taiwan, 500-06[118]Chang Gung Medical Foundation - Kaohsiung Chang Gung Memorial Hospital Kaohsiung, Taiwan, 833[119]China Medical University Hospital Taichung, Taiwan, 40447[120]Chi Mei Medical Center Tainan, Taiwan, 710[121]Chi Mei Hospital, Liouying Tainan, Taiwan, 73657[122]National Taiwan University Hospital Taipei, Taiwan, 100[123]Taipei Veterans General Hospital Taipei, Taiwan, 11217[124]Guys & St. Thomas Hospital London, United Kingdom, SE1 9RT[125]St. George's Hospital London, United Kingdom, SW17 0RE[126]The Royal Marsden NHS Foundation Trust London, United Kingdom, SW3 6JJ[127]Imperial NHS Trust London, United Kingdom, W12 0HS[128]Sarah Cannon Research Institute-London London, United Kingdom, W1G 6AD[129]The Christie NHS Foundation Trust Manchester, United Kingdom, M20 4BX[130]Mount Vernon Cancer Centre Northwood, United Kingdom, HA6 2RN[131]The Royal Marsden NHS Foundation Trust - Haemato-Oncology Sutton, United Kingdom, SM2 5PT[132]New Cross Hospital Wolverhampton, United Kingdom, WV10 0QP[133]St. Joseph Heritage Healthcare Fullerton, California, United States, 92835
The purpose of this study is to evaluate the efficacy and safety of tislelizumab as second line treatment in participants with advanced unresectable/metastatic ESCC that has progressed during or after first line therapy.
