研究单位：[1]Xcovery Holding Company, LLC[2]Moffitt Cancer Center Tampa, Florida, United States, 33612[3]University Cancer & Blood Center Athens, Georgia, United States, 30607[4]Kaiser Permanente Hawaii- Moanalua Medical Center Honolulu, Hawaii, United States, 96819[5]Saint Alphonsus Regional Medical Center Boise, Idaho, United States, 83706[6]Henry Ford Hospital Detroit, Michigan, United States, 48202[7]Washington University School of Medicine Saint Louis, Missouri, United States, 63110[8]North Shore Hematology-Oncology Associates, PC East Setauket, New York, United States, 11733[9]Providence Portland Medical Center Portland, Oregon, United States, 97213[10]Vanderbilt University Nashville, Tennessee, United States, 37240[11]Inova Schar Cancer Institute Fairfax, Virginia, United States, 22031[12]Providence Regional Cancer System Lacey, Washington, United States, 98503[13]University of Wisconsin Clinical Science Center Madison, Wisconsin, United States, 53792[14]CEMIC Buenos Aires, Argentina[15]Fundacion Favaloro Caba, Argentina[16]Centro de Investigacion Pergamino SA Pergamino, Argentina[17]Sanatorio Parque S.A. Rosario, Argentina[18]Border Medical Oncology Research Unit Albury, New South Wales, Australia, 2640[19]Chris O'Brien Lifehouse Camperdown, New South Wales, Australia[20]Princess Alexandra Hospital Woolloongabba, Queensland, Australia[21]Chris O Brien Lifehouse Camperdown, Australia[22]Princess Alexandra Hospital Woolloongabba, Australia[23]UZ Brussel Brussels, Belgium, 1090[24]CHU UCL Namur Yvoir, Belgium, 5530[25]Instituto do Câncer do Estado de São Paulo São Paulo, SP, Brazil, 01246-000[26]Hospital de Câncer de Barretos - Fundação Pio XII São Paulo, SP, Brazil, 14784-400[27]Hospital Haroldo Juaçaba - Instituto do Cancêr do Ceará Fortaleza, Brazil, 60351-010[28]Núcleo de Oncologia da Bahia - NOB Salvador, Brazil, 40170-110[29]Fundacao do ABC Faculdade de Medicina do ABC Santo André, Brazil, 09060-650[30]Hospital Paulistano São Paulo, Brazil, 01321[31]Cross Cancer Institute Edmonton, Alberta, Canada, T6G 1Z2[32]Infirmière recherche Clinique, IUCPQ Quebec City, Quebec, Canada, G1V 4G5[33]Anhui Provincial Hospital Hefei, Anhui, China, 230001[34]Beijing Chao Yang Hospital Beijing, Beijing, China, 100020[35]Peking Union Medical College Hospital Beijing, Beijing, China, 100032[36]Peking University Cancer Hospital Beijing, Beijing, China, 100142[37]Beijing Chest Hospital,Capital Medical University Beijing, Beijing, China, 101149[38]Fujian Provincial Cancer Hospital Fuzhou, Fujian, China, 350014[39]Guangdong General Hospital Guangzhou, Guangdong, China, 510080[40]Fourth Hospital of Hebei Medical University Shijiazhuang, Hebei, China, 050011河北医科大学第四医院[41]Union Hospital of Tongji Medical College of Huazhong Science and Techology University Wuhan, Hubei, China, 420104[42]Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology Wuhan, Hubei, China, 430030[43]Hubei Cancer Hospital Wuhan, Hubei, China, 430079[44]Hunan Cancer Hospital Changsha, Hunan, China, 410006[45]Nanjing General Hospital Nanjing, Jiangsu, China, 210002[46]The Second Affiliated Hospital of Nanchang University Nanchang, Jiangxi, China, 330006[47]The First Bethune Hospital of Jilin University Changchun, Jilin, China, 130000[48]Jilin Cancer Hospital Changchun, Jilin, China, 130012[49]The First Hospital of China Medical University Shenyang, Liaoning, China, 110001[50]The Affiliated Hospital of Qingdao University Qingdao, Shandong, China, 266071[51]Shanghai Chest Hospital Shanghai, Shanghai, China, 200030[52]West China Hospital, Sichuan University Chengdu, Sichuan, China, 610041[53]Tianjin Medical University General Hospital Mailing No.154 Anshan Avenue Heping District Tianjin, Tianjin, China, 300052[54]Zhejiang Cancer Hospital Hangzhou, Zhejiang, China, 310022[55]Beijing Cancer Hospital Beijing, China, 100142[56]Peking University Cancer Hospital Beijing, China, 100142[57]Beijing Cancer Hospital Beijing, China[58]The First Affiliated Hospital, Zhejiang University Hangzhou, China[59]Zhejiang Cancer Hospital Hangzhou, China[60]Vítkovická Nemocnice , a.s. Ostrava-Vitkovice, Czechia, 70384[61]Nemocnice Na Pleši s.r.o. Plesice, Czechia, 26204[62]Krajská zdravotní, a.s., Masarykova nemocnice Usti nad Labem, Czechia, 40113[63]Hopital Morvan CHRU de Brest Brest, France, 29200[64]Centre GF Leclerc Dijon, France, 21000[65]CHRU Lille Lille, France, 59000[66]ICM Val d'Aurelle Montpellier, France, 34298[67]Hôpital Saint-Louis Paris, France, 75010[68]CHU de Rennes Hôpital Pontchaillou Rennes, France, 35033[69]Institut de Cancérologie de l'Ouest (ICO) Saint Herblain, France, 44805[70]Nouvel Hospital Civil de Stasbourg Strasbourg, France, 67091[71]Klinik m. S. Infektiologie & Pneumologie Berlin, Germany, 13353[72]Vivantes Klinikum Neukölln Berlin, Germany, D-12351[73]Lungen Clinic Grosshansdorf Grosshansdorf, Germany, 22927[74]Klinik Löwenstein gGmbH Med. Klinik II Onkologie Lowenstein, Germany, 74245[75]Praxis Hämatologie und Onkologie Stolberg Stolberg, Germany, D-52222[76]Queen Elizabeth Hospital Hong Kong, Hong Kong[77]The University of Hong Kong, Queen Mary Hospital Hong Kong, Hong Kong[78]The University of Hong Kong/Queen Mary Hospital Hong Kong, Hong Kong[79]Prince of Wales Hospital Sha Tin, Hong Kong[80]Soroka Medical Centre Be'er Sheva', Israel, 84101[81]Rambam Health Care Campus/ Oncology Institute Haifa, Israel, 31096[82]Hadassah Medical Center Jerusalem, Israel, 9112001[83]Rabin Medical Center Institute of Oncology, Davidoff Center Petah Tiqva, Israel, 49100[84]Chaim Sheba Medical Center Ramat Gan, Israel, 5262000[85]Centro Riferimento Oncologico CRO Aviano Aviano, Italy, 33081[86]Ospedale Mater Salutis Legnago, Italy, 37045[87]IRCCS - Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) Meldola, Italy, 47014[88]IEO Istituto Europeo di Oncologia Milano, Italy, 20141[89]AOU Federico II, Oncologia Medica Napoli, Italy, 80131[90]Centro Operativo Studi Clinici S.C.Oncologia Medica Perugia, Italy, 06132[91]UOC Oncologia Medica Ravenna, Italy, 48121[92]Istituto Clinico Humanitas IRCCS Rozzano, Italy, 20089[93]Azienda Socio Sanitaria Territoriale (ASST) della Valtellina e dell'Alto Laria Sondrio, Italy, 20121[94]Seoul National University Hospital Seoul, Korea, Republic of, 03080[95]Asan Medical Center Seoul, Korea, Republic of, 05505[96]VU Medical Center Amsterdam, Netherlands, 1007 MB[97]Maastricht University Medical Centre (MUMC) Maastricht, Netherlands, 6229HX[98]Clínica Ricardo Palma Lima, Peru[99]Medical University of Gdansk Gdańsk, Poland[100]Centrum Onkologii-Instytut im. M. Sklodowskiej Curie Warsaw, Poland[101]Federal State Budgetary Scientific Institution Russian Oncological Scientific Center named after N.N. Blokhin Moscow, Russian Federation, 115478[102]LLC "Vitamed" Moscow, Russian Federation, 121309[103]State Budgetary Institution of Healthcare of the city of Moscow "MOSCOW CITY ONCOLOGY HOSPITAL # 62" Moscow, Russian Federation, 143423[104]BHI of Omsk region "Clinical Oncology Dispensary" Omsk, Russian Federation[105]Pavlov First Medical University Saint Petersburg, Russian Federation, 197022[106]FBI "Scientific Research Institute of Oncology n. a. N. N. Petrov" Saint Petersburg, Russian Federation[107]Clinica Universidad de Navarra Pamplona, Navarra, Spain, 31008[108]Hospital Universitario Infanta Cristina Badajoz, Spain, 06080[109]Hospital del Mar Barcelona, Spain, 08003[110]Hospital de la Santa Creu i Sant Pau Barcelona, Spain, 08025[111]Hospital Universitario Quirón Dexeus Barcelona, Spain, 08028[112]Hospital Vall d'Hebrón Barcelona, Spain, 08035[113]Hospital Parc Tauli' Barcelona, Spain, 08208[114]ICO Girona - Hospital Doctor Josep Trueta Girona, Spain, 17007[115]Hospital General Universitario Gregorio Marañon Madrid, Spain[116]Hospital Son Ltatzer Palma de Mallorca, Spain, 07198[117]Trakya University Balkan Oncology Hospital Edirne, Turkey, 22030[118]Istanbul University Cerrahpasa Medical Faculty Istanbul, Turkey, 34098[119]Ege University Medical Faculty Izmir, Turkey, 35100[120]Blackpool Victoria Hospital Blackwood, United Kingdom, FY3 8NR[121]Southmead Hospital Bristol, United Kingdom, BS10 5NB[122]Kings Mill hospital Nottingham, United Kingdom, NG17 4JL[123]The Clatterbridge Cancer Centre NHS Foundation Trust Wirral, United Kingdom, CH63 4JY[124]Mayo Clinic Phoenix, Arizona, United States, 85054
The primary purpose of this study is to evaluate the efficacy and safety of X-396 (ensartinib) vs. crizotinib in patients with ALK-positive non-small cell lung cancer that have received up to 1 prior chemotherapy regimen and no prior ALK inhibitor.
